疫苗接种系统干预审查的方法质量
Antonia Pilic1,2, Louise Henaff3, Christoph A Steffen3
1Robert Koch Institute, Immunization Unit, Berlin, Germany. pilicA@rki.de.
大多数疫苗接种系统审查 (SRs) 都存在关键的方法缺陷,影响了可靠性. 提高标准的遵守和透明度对于基于证据的疫苗接种决策至关重要.
科学领域:
- 公共卫生 公共卫生
- 证据综合 证据综合
- 疫苗学 疫苗学 疫苗学
背景情况:
- 系统性审查 (SRs) 对于制定疫苗推至关重要.
- 特别报告的方法质量直接影响其发现的可靠性.
- 本研究评估了与疫苗接种相关的SR质量,并确定了影响它的因素.
研究的目的:
- 评估与疫苗接种相关的系统审查的方法质量.
- 确定影响这些审查质量的因素.
主要方法:
- 分析了2011-2023年间发表的120份疫苗接种SR.
- 使用AMSTAR 2 (评估系统性审查的测量工具2) 评估方法质量.
- 统计分析 (曼 - 惠特尼U,奇平方,费舍尔精确的多变量回归) 确定了影响质量得分的因素.
主要成果:
- 在120个SR中,有110个被评为质量极低的.
- 常见的缺陷包括没有理由将研究排除在外,没有注册协议.
- 较高的质量与较晚的出版日期 (2017年以后),科克莱恩评论和没有利益冲突的作者有关.
结论:
- 与疫苗接种相关的SRs表现出显著的方法缺陷.
- 遵守方法标准和提高透明度至关重要.
- 提高SR质量将增强它们对个人和政策决策的影响.
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