怀孕期间益乳素水平升高会影响结直肠癌的攻击性
Maria Lopez-Cavestany1, Olivia A Wright1, Alexandria T Carter2
1Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, 37212, USA.
BMC biology
|January 8, 2026
概括
怀孕相关的益生菌 (PRL) 通过激活JAK2/STAT3和JAG1/NOTCH1信号来增加结直肠癌 (CRC) 的攻击性. 基于 TRAIL 的疗法在治疗孕妇 CRC 患者方面表现有前途.
科学领域:
- 在瘤学瘤学.
- 生殖医学 生殖医学
- 分子生物学分子生物学
背景情况:
- 怀孕期间结肠直肠癌 (CRC) 带来了独特的挑战,包括在诊断时的晚期和有限的治疗选择.
- 怀孕与前素 (PRL) 水平升高有关,这可能会影响癌症的攻击性.
研究的目的:
- 调查怀孕期PRL和CRC攻击性之间的机制联系.
- 探索潜在的怀孕兼容的治疗策略,用于CRC.
主要方法:
- 在体外研究中,CRC细胞暴露于怀孕阶段的PRL.
- 对JAK2/STAT3信号通路的计算建模.
- 怀孕的CRC患者的临床数据审查.
主要成果:
- 怀孕阶段的PRL增强了JAK2/STAT3和JAG1/NOTCH1的信号传递,促进了表皮细胞-介质细胞过渡 (EMT) 和CRC细胞中的癌症干状特征.
- 计算建模确定了JAK2/STAT3通路中对PRL.敏感的关键节点.
- 怀孕的CRC患者在更先进的阶段被诊断出来,由于胎儿安全问题,治疗选择有限.
- 暴露于PRL使CRC细胞对TRAIL诱导的亡敏感,这表明基于TRAIL的疗法是可行的选择.
结论:
- 通过JAK2/STAT3和JAG1/NOTCH1信号,建立了怀孕PRL和CRC攻击性增加之间的第一个机制联系.
- 强调基于TRAIL的疗法,特别是脂质体配方在治疗孕妇CRC患者中的潜力.
- 强调迫切需要新,安全和有效的治疗策略来治疗怀孕期间的CRC.
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