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精子DNA碎片化和辅助生殖:一个总体的元分析

Bangbei Wan^1,2, Yu Fu³, Ning Ma³

¹Reproductive Medical Center, Hainan Women and Children's Medical Center, No. 75, Longkun South Road, Haikou, Hainan, China. 939313612@qq.com.

European journal of medical research

|January 8, 2026

概括

高精子DNA碎片化 (SDF) 对辅助生殖技术 (ART) 的成功率产生负面影响,特别是在试管婴儿和IUI. 虽然其对ICSI的影响较弱,但SDF升高与ICSI周期中妊娠损失增加有关.

科学领域:

生殖医学生殖医学
男人不孕症研究研究
辅助生殖技术 (ART) 是一种辅助生殖技术.

背景情况:

男性不孕症对全球不孕症问题做出了重大贡献.
传统的精液分析对精子功能的洞察力有限.
精子DNA碎片化 (SDF) 是精子核质量的潜在指标,但其在ART中的临床实用性仍有争议.

研究的目的:

执行现有元分析的总体元分析.
评估SDF和关键ART结果之间的关联:临床妊娠 (CP),妊娠流产 (PL) 和活产率 (LBR).

主要方法:

在主要数据库 (PubMed,Embase,Web of Science,Scopus,Cochrane Library) 进行系统的文献搜索,截至2025年7月.
包括系统性审查与SDF在IVF,ICSI和IUI中的元分析.
使用AMSTAR-2和GRADE框架评估证据质量.

主要成果:

分析了8个覆盖超过25,000个ART周期的元分析.
增加的SDF与IVF和IUI中的CP降低相关,以及ICSI中的边界关联.
在ICSI周期中,高的SDF与增加的PL有很强的关联.
关于LBR的证据有限且不确.
由于异质性和方法上的局限性,总体证据确定性很低.

结论:

增加的SDF会对ART的结果产生不利影响,特别是在试管婴儿和IUI中.
在ICSI结果中发现了一个微弱的关联,但在ICSI中观察到与流产的强烈联系.
结果强调了SDF的预后价值,但强调了对标准化测试和进一步的临床整合前性研究的需要.

关键词:

辅助生殖技术是一种辅助生殖技术.在体外受精 (IVF)在细胞体内注射精子 (ICSI)宫内授精 (IUI) 是指宫内授精.精子DNA碎片化的情况

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