没有防腐剂的效果和安全性与防腐剂的蒂莫洛尔眼药滴在青光眼中:一个随机交叉研究
Yen-Huei Ko1, Chia-Chi Fan2, Yu-Chieh Ko3,4
1Department of Optometry, Kang Ning University, Taipei, Taiwan, ROC.
Journal of the Chinese Medical Association : JCMA
|January 8, 2026
概括
与未使用防腐剂的提摩洛尔眼药相比,无防腐剂的提摩洛尔眼药显示出较大的初始眼内压降低和改善的眼睛安全性. 这使得无防腐剂的蒂莫洛尔成为治疗青光眼的潜在安全选择.
科学领域:
- 眼科医生 眼科 眼科
- 玻璃眼研究研究 玻璃眼研究
- 药理学 药理学是指药理学的学科.
背景情况:
- 对于无防腐剂的提摩洛尔 (PF-timolol) 与保存的提摩洛尔 (P-timolol) 在初级开角玻璃眼瘤 (POAG) 和眼睛高血压 (OHT) 中存在有限的比较数据.
- 评估这些配方的疗效和安全性对于优化青光眼治疗至关重要.
研究的目的:
- 为了比较PF-timolol与P-timolol在POAG或OHT患者的疗效和安全性.
- 评估眼内压力 (IOP) 降低,眼表面健康状况以及患者报告的症状.
主要方法:
- 这是一项随机,交叉,单中心研究,涉及34名患者.
- 患者每天接受两次PF-timolol或每天一次P-timolol,持续6周,然后进行交叉治疗.
- 主要终点:眼内压力 (IOP) 的变化;次要终点:膜破裂时间 (TBUT),表面点状角膜病变 (SPK) 评分,高血压,生命体征和症状.
主要成果:
- 在第6周,PF-timolol在右眼的IOP降低显著增加 (p=0.004).
- 使用PF-timolol改善了TBUT,而使用P-timolol则降低了TBUT (p=0.006).
- 在第12周,PF-timolol显示了SPK得分的更大降低 (p=0.03) 和可比的IOP降低.
结论:
- 与P-timolol相比,PF-timolol实现了优异的初始IOP降低和增强的眼睛安全结果.
- 提摩洛 (PF-timolol) 提供了一种有效和更安全的替代品来治疗青光眼,特别是对于对防腐剂敏感的患者.
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