对局部复发的鼻癌进行同情的子中子捕获疗法:一项回顾性研究
Ling-Wei Wang1,2, Yen-Wan Hsueh Liu3, Jinn-Jer Peir4
1Department of Heavy Particles and Radiation Oncology, Taipei Veterans General Hospital, Taipei, Taiwan, ROC.
Journal of the Chinese Medical Association : JCMA
|January 8, 2026
概括
慈悲使用子中子捕获疗法 (BNCT) 显示,复发性鼻癌 (NPC) 的应答率为25%. 这种粒子辐射疗法提供了一个潜在的治疗选择,其中一名患者存活超过4年.
科学领域:
- 在瘤学瘤学.
- 辐射疗法 辐射疗法
- 微粒疗法是一种微粒疗法.
背景情况:
- 中子捕获疗法 (BNCT) 是一种先进的粒子放射疗法技术.
- 与传统的光子辐射疗法相比,BNCT提供了优越的正常组织节约.
- 这项研究侧重于在放射治疗后对复发性鼻癌 (rNPC) 的同情使用BNCT.
研究的目的:
- 评估同情使用BNCT对复发性鼻癌患者的安全性和有效性.
- 评估该患者队列的治疗反应和生存结果.
主要方法:
- 在2020年至2024年期间,对10名rNPC患者接受BNCT治疗的回顾性分析.
- 患者在清华开放式水池反应堆接受了BNCT.
- 随访时间中位数为10.7个月,记录了剂量和毒性.
主要成果:
- 在8个可评估病例中观察到25%的应答率 (1个完整的,1个部分的应答).
- 常见的毒性包括低度的粘膜炎和皮肤炎;没有动脉爆发综合征.
- 一年总生存率为44.4%,无进展生存率为33%,其中有一个长期幸存者 (>4年).
结论:
- 富有同情心的BNCT在rNPC中显示出适度的反应率和长期生存潜力.
- 未来的试验可能会通过调整剂量分离和组合疗法来改善结果.
- 对于选择的rNPC案例,BNCT是一个可行的选择.
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