[在儿童血液造血干细胞移植后对扭矩微型病毒感染的临床分析]
Ye-Ping Sheng1, Ling-Jun Kong2, Pei-Pei Chu1
1Department of Hematology, Suzhou Wujiang District Children's Hospital,Suzhou 215000, Jiangsu Province, China.
Zhongguo shi yan xue ye xue za zhi
|January 8, 2026
概括
扭矩病毒 (TTV) 感染在血造干细胞移植 (HSCT) 后的儿童中很常见,影响了42.5%的患者. TTV感染与细胞巨乳病毒和移植与宿主疾病的风险增加有关,影响临床结果.
科学领域:
- 病毒学 病毒学
- 免疫学 免疫学 免疫学
- 儿科血液学/瘤学
背景情况:
- 造血干细胞移植 (HSCT) 是儿童血液病的关键治疗方法.
- 移植后感染对儿科患者构成重大风险.
- 扭矩病毒 (TTV) 是一种常见的,但往往无症状的病毒,在免疫受损人群中影响不完全理解.
研究的目的:
- 为了确定发生率和临床特征的Torque teno病毒 (TTV) 感染在儿童后HSCT.
- 为了确定与HSCT后的TTV感染相关的潜在风险因素.
- 在这个儿科队列中调查TTV感染的并发症和临床影响.
主要方法:
- 甲基因组下一代测序 (mNGS) 用于检测HSCT后儿科患者血液中的病毒基因序列.
- 分析了40名为血液病接受HSCT的儿童的临床数据.
- 进行了统计分析,以比较TTV阳性和TTV阴性组,并确定相关因素和并发症.
主要成果:
- 在HSCT后的儿科患者中,TTV感染的发生率为42.5% (17/40).
- 在接受平分相同的HSCT的儿童和以骨髓干细胞 (BMSC) 作为移植来源的儿童中,TTV感染的发生率明显高.
- 受TTV感染的儿童患上移植对宿主疾病 (GVHD) 的发病率较高,并经常与细胞巨血病毒,人类多瘤病毒和爱斯坦-巴尔病毒共同感染.
结论:
- 扭矩病毒 (TTV) 感染在接受HSCT的儿童中很常见.
- 转录病毒感染与并发症的风险增加有关,特别是细胞巨乳病毒联合感染和移植对宿主疾病 (GVHD).
- 这些发现突出了TTV感染对儿科HSCT接受者的临床结果的显著影响.
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