在精神分裂症患者中,每3个月和每1个月的帕利皮里顿棕酸盐配方之间的副作用比较
Erkan Kuru1, Ilker Ozdemir2, Bengu Yucens3
1Private Practice, Psychiatry, Ankara, Turkey.
Human psychopharmacology
|January 8, 2026
概括
从帕利佩里棕酸1个月 (PP1M) 转换为3个月 (PP3M) 注射,并没有增加精神分裂症患者的副作用. 便秘减少,整体副作用负担保持稳定.
科学领域:
- 精神病学是一个精神病学.
- 药理学 药理学是指药理学的学科.
- 临床医学 临床医学
背景情况:
- 帕利皮里棕酸3个月 (PP3M) 提供了超过PP1M的延长剂量.
- 关于PP1M与PP3M副作用概况的现实数据有限.
- 这项研究比较了精神分裂症患者的PP1M和PP3M之间的副作用.
研究的目的:
- 为了比较paliperidone palmitate1个月 (PP1M) 和3个月 (PP3M) 配方的副作用概况.
- 评估从PP1M切换到PP3M的患者的副作用变化.
主要方法:
- 使用了患者内部的镜像设计.
- 副作用使用UKU副作用评分尺度进行评估.
- 症状严重程度使用负面症状评估尺度和积极症状评估尺度进行评估.
主要成果:
- 在切换到PP3M后,没有观察到UKU整体副作用负担的增加.
- 最常见的副作用包括疲劳,低运动,体重增加和两种配方的性欲下降.
- 在转换为PP3M后,便秘明显减少;多种抗精神病药物时,副作用更为普遍.
结论:
- 从PP1M转换为PP3M与增加的副作用负担无关.
- 优化剂量选择和偏好单一治疗可能会改善治疗舒适度.
- 这些发现可以指导临床医生选择长效注射抗精神病药物.
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