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Updated: Jun 12, 2026

Methods for Studying the Mechanisms of Action of Antipsychotic Drugs in Caenorhabditis elegans
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在虫Caenorhabditis elegans中的一个阴阳两药物 (CAD) 防御系统

Levon Tokmakjian, Duhyun Han, Kateryna Sihuta

    bioRxiv : the preprint server for biology
    |January 8, 2026
    PubMed
    概括

    阴离子两性药物 (CAD) 破坏细胞功能,导致脂化症. 在C. elegans中,CADs激活了一种涉及CYP-35B酶和PGP-13的防御系统,这对于药物代谢和排毒至关重要.

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    Anthelmintic drugs differ significantly from antiparasitic therapies targeting protozoa, primarily due to differences in parasite biology. Whereas most protozoal treatments act on proliferating cells, anthelmintics are typically directed against mature, nonproliferative helminths. The therapeutic approach considers the helminth's reliance on neuromuscular coordination, glucose metabolism, and microtubular integrity for survival, reproduction, and localization within the host. Most anthelmintics...