Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Disorders of the Nervous Tissue01:28

Disorders of the Nervous Tissue

2.5K
Nervous tissue is a vital component of the human body's communication system, enabling us to perceive and respond to stimuli. However, like all other tissues, it is vulnerable to disorders and diseases that can significantly impact our neurological functioning.
Homeostatic Imbalances:
Alzheimer's disease manifests as a gradual decline in memory and cognitive abilities, attributed to the buildup of amyloid plaques and neurofibrillary tangles in the brain.
Parkinson's disease arises from the...
2.5K
Drugs Affecting Neurotransmitter Synthesis01:29

Drugs Affecting Neurotransmitter Synthesis

2.1K
Drugs affecting neurotransmitter synthesis can impact the adrenergic neuron and the synthesis of neurotransmitters. For example, α-methyltyrosine and carbidopa target specific enzymes involved in catecholamine synthesis. α-methyltyrosine inhibits the enzyme tyrosine hydroxylase, which converts tyrosine into dopamine. By blocking this enzyme, α-methyltyrosine reduces dopamine production and other catecholamines. Carbidopa, on the other hand, inhibits the enzyme dopa decarboxylase,...
2.1K
Role of Neurotransmitters in Memory01:23

Role of Neurotransmitters in Memory

2.5K
Neurotransmitters are integral to the brain's communication system, enabling neurons to transmit signals across synapses. This chemical exchange underpins various cognitive functions, including memory processes. The role of neurotransmitters in memory is multifaceted, influencing the encoding, consolidation, and retrieval of memories through their action on different neural circuits.
 Glutamate and Synaptic Plasticity
Glutamate, the brain's main excitatory neurotransmitter, is...
2.5K
Alzheimer's Disease: Overview01:26

Alzheimer's Disease: Overview

1.6K
Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
1.6K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Metabolic crisis and TRPM4 activation cause QT prolongation in TANGO2 deficiency disorder.

Cardiovascular research·2026
Same author

Correction: Sez6L2 inhibits complement by facilitating factor I cleavage of C3b and accelerating the decay of C3 convertases.

Frontiers in immunology·2026
Same author

Genetic background shapes SEZ6L2 autoimmunity and reveals coordinated immune responses linked to neurological dysfunction.

bioRxiv : the preprint server for biology·2026
Same author

Dynamics of neutrophilia at the neurovascular unit arising from repeated pulmonary inflammation.

Journal of neuroinflammation·2026
Same author

New onset seizure etiologies and outcomes among adults with HIV in the era of broadly available antiretroviral therapies.

Seizure·2026
Same author

Electrical stimulation of the vagus nerve improves amyloid pathology in delirium superimposed on dementia.

Bioelectronic medicine·2026

相关实验视频

Updated: Jan 13, 2026

A Fine Motor Task to Study Joint Kinematics in a Preclinical Model of Neurodegenerative Disease
05:39

A Fine Motor Task to Study Joint Kinematics in a Preclinical Model of Neurodegenerative Disease

Published on: June 13, 2025

775

失去SEZ6L2会破坏运动协调,认知功能和突触连接.

Julia M Granato1, Nina Silver2, Alison Hobbins2

  • 1Neuroscience Graduate Program, University of Rochester Medical Center, Rochester, NY.

bioRxiv : the preprint server for biology
|January 8, 2026
PubMed
概括

SEZ6L2基因对大脑功能至关重要,影响运动技能,社会行为和突触健康. 它的缺失导致了严重的神经发育问题,突出了SEZ6L2的问题.

关键词:
这里是SEZ6 SEZ6.这里是SEZ6L.在SEZ6L2中.行为行为行为行为行为.皮层 皮层 皮层运动协调运动协调神经元神经元的神经元

更多相关视频

Real-Time Fluorescent Measurement of Synaptic Functions in Models of Amyotrophic Lateral Sclerosis
08:59

Real-Time Fluorescent Measurement of Synaptic Functions in Models of Amyotrophic Lateral Sclerosis

Published on: July 16, 2021

3.1K
Locomotor Assessment of 6-Hydroxydopamine-induced Adult Zebrafish-based Parkinson's Disease Model
07:32

Locomotor Assessment of 6-Hydroxydopamine-induced Adult Zebrafish-based Parkinson's Disease Model

Published on: December 28, 2021

4.3K

相关实验视频

Last Updated: Jan 13, 2026

A Fine Motor Task to Study Joint Kinematics in a Preclinical Model of Neurodegenerative Disease
05:39

A Fine Motor Task to Study Joint Kinematics in a Preclinical Model of Neurodegenerative Disease

Published on: June 13, 2025

775
Real-Time Fluorescent Measurement of Synaptic Functions in Models of Amyotrophic Lateral Sclerosis
08:59

Real-Time Fluorescent Measurement of Synaptic Functions in Models of Amyotrophic Lateral Sclerosis

Published on: July 16, 2021

3.1K
Locomotor Assessment of 6-Hydroxydopamine-induced Adult Zebrafish-based Parkinson's Disease Model
07:32

Locomotor Assessment of 6-Hydroxydopamine-induced Adult Zebrafish-based Parkinson's Disease Model

Published on: December 28, 2021

4.3K

科学领域:

  • 神经科学是一个神经科学.
  • 遗传学 遗传学是一种遗传学.
  • 分子生物学分子生物学

背景情况:

  • SEZ6基因家族 (SEZ6,SEZ6L,SEZ6L2) 对神经发育,突触组织和补充调节至关重要.
  • SEZ6L2在大脑功能中的特定作用尚不清楚.
  • 了解SEZ6L2的功能是解读神经发育和神经退行性疾病的关键.

研究的目的:

  • 为了全面描述Sez6l2淘汰赛 (KO) 鼠的行为和神经生物学表型.
  • 为了比较Sez6l2 KO表型与Sez6三次淘汰赛 (TKO) 鼠标.
  • 阐明SEZ6L2在大脑功能中的非冗余作用.

主要方法:

  • 在Sez6l2 KO小鼠的生成和行为测试中.
  • 将Sez6l2 KO小鼠与Sez6 TKO小鼠进行比较.
  • 神经生物学分析包括突触结构和蛋白质表达.

主要成果:

  • Sez6l2 KO小鼠在运动协调,步行,社交,感官处理和重复行为方面表现出缺陷.
  • 在Sez6l2 KO小鼠中,运动缺陷和一些行为表型随着年龄的增长而恶化.
  • 减少的树突脊柱长度和减少的突触后蛋白质表达表明Sez6l2KO小鼠的刺激突触连接性受损.
  • Sez6 TKO小鼠表现出比Sez6l2 KO小鼠更严重的损伤.

结论:

  • SEZ6L2是运动,认知和突触功能的关键和非冗余调节器.
  • SEZ6L2功能障碍有助于神经发育和神经退行性疾病.
  • 这项研究提供了关于SEZ6家族在大脑健康中的作用的机制性见解.