相关实验视频

Updated: Jan 13, 2026

Preparation and Evaluation of 99mTc-labeled Tridentate Chelates for Pre-targeting Using Bioorthogonal Chemistry

Preparation and Evaluation of 99mTc-labeled Tridentate Chelates for Pre-targeting Using Bioorthogonal Chemistry

Published on: February 4, 2017

一种新的标签方法 99m Tc-PSMA-HBED-CC

Benchamat Phromphao^1,2, Shuichi Shiratori³

¹Medical Physics Program, Department of Radiology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.

World journal of nuclear medicine

|January 8, 2026

概括

一种新的制备技术-99m标记前列腺特异性膜抗原向成像剂的新方法 (99mTc-PSMA-HBED-CC) 为前列腺癌诊断提供了比-68 PSMA-HBED-CC更容易获得和更实惠的替代方案. 这一发展旨在改善世界各地的PET成像可用性.

科学领域:

核医学就是核医学.
放射性药物化学放射性药物化学
瘤成像学成像学

背景情况:

-68 PSMA-HBED-CC (68Ga-PSMA-11) 是FDA批准的一种针对前列腺癌的PSMA向PET成像药物.
由于PET/CT,PET/MR和68Ga的可用性受到限制,因此68Ga-PSMA-HBED-CC的广泛使用受到阻碍.
开发一种替代成像剂对于更广泛的临床应用至关重要.

研究的目的:

开发99mTc-PSMA-HBED-CC的内部制备方法,作为一种无处不在且负担得起的替代方案.
为了优化放射性标记条件,以获得高放射性化学产量和纯度.
为了评估开发的99mTc-PSMA-HBED-CC.的稳定性.

主要方法:

用99mTc-pertechnetate对PSMA-HBED-CC进行放射性标记,使用SnCl2·2H2O作为减少剂.
优化标签参数,包括试剂量,温度和化时间.
使用即时薄层染色学进行质量控制,以评估放射化学纯度和稳定性.

主要成果:

在最佳条件下成功进行99mTc-PSMA-HBED-CC的放射性标记:10微克PSMA-HBED-CC,3微克SnCl2·2H2O和370MBq99mTc-pertechnetate在100°C进行15分钟.
获得了高放射性化学产量 (71.49 ± 2.42%),放射性化学纯度 (98.29 ± 2.65%) 和特定活性 (37.84 ± 1.47 GBq/μmol).
99mTc-PSMA-HBED-CC合物表现出稳定性,在室温下保持>95%的放射性化学纯度长达4小时.

结论:

一种针对99mTc-PSMA-HBED-CC的新且高效的标签方法已经成功开发出来.
99mTc-PSMA-HBED-CC的质量控制参数符合欧洲药典的标准.
这种方法为前列腺癌患者的PSMA向PET成像提供了一个有希望的,可访问的和具有成本效益的替代方案.

关键词:

99m Tc-PSMA-HBED-CC 这是一个很好的方法.在PSMA-11中,它是PSMA-11的.这就是PSMA-HBED-CCCC.前列腺癌是前列腺癌.技术-99m是一种

更多相关视频

Enhancing Efficiency and Radiolabeling Yields of Carbon-11 Radioligands for Clinical Research Using the Loop Method

Enhancing Efficiency and Radiolabeling Yields of Carbon-11 Radioligands for Clinical Research Using the Loop Method

Published on: December 20, 2024

Positron Emission Tomography Imaging of Cell Trafficking: A Method of Cell Radiolabeling

Positron Emission Tomography Imaging of Cell Trafficking: A Method of Cell Radiolabeling

Published on: October 27, 2023

相关概念视频

Imaging Studies II: Positron Emission Tomography and Scintigraphy

Imaging Studies II: Positron Emission Tomography and Scintigraphy

Positron Emission Tomography (PET) is a medical imaging technique that provides crucial insights into the body's physiological functions at a molecular level. It is an indispensable resource for diagnosing, staging, and monitoring various illnesses, notably cancer, neurological disorders, and cardiovascular conditions.
Fundamental Principles of PET

Positron Emission Tomography

Positron Emission Tomography

Positron emission tomography (PET) is a medical imaging technique involving radiopharmaceuticals — substances that emit short-lived radiation. Although the first PET scanner was introduced in 1961, it took 15 more years before radiopharmaceuticals were combined with the technique and revolutionized its potential.
One of the main requirements of a PET scan is a positron-emitting radioisotope, which is produced in a cyclotron and then attached to a substance used by the part of the body...