在治疗勃起功能障碍方面,按需使用的西尔德纳菲尔,塔达拉菲尔和每日使用的塔达拉菲尔的比较疗效:一项为期12周的随机对照研究
Shevya Gagal1, Ajeet K Sidana1, Abhinav Agrawal1
1Department of Psychiatry, Government Medical College and Hospital, Chandigarh, India.
Indian journal of psychiatry
|January 8, 2026
概括
与按需服用的西尔德纳菲尔或塔达拉菲尔相比,每日服用塔达拉菲尔显著改善了勃起功能,并减少了抑郁和焦虑症状. 按需的塔达拉菲尔在勃起功能障碍患者的早泄中最有效.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 精神病学是一个精神病学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 印度一线勃起功能障碍 (ED) 治疗的有效性需要进一步比较.
- 勃起障碍经常与精神健康障碍同时发生,因此需要评估治疗对精神症状的影响.
研究的目的:
- 为了比较Sildenafil按需,Tadalafil按需和每日Tadalafil在ED治疗疗效方面.
- 评估这些治疗对早泄和心理健康的影响.
主要方法:
- 75名患有ED的男性被随机分为三组:西尔德纳菲尔 (按需),塔达拉菲尔 (按需) 和塔达拉菲尔 (每天).
- 在12周内评估勃起功能 (IIEF,SEP2/3),PME (PEDT) 和心理健康 (DASS-21).
- 血液测试在基线和研究结束时进行.
主要成果:
- 每日使用的塔达拉菲尔显示出优异的勃起功能改善 (P <0.05),特别是透,与按需的西尔德纳菲尔和塔达拉菲尔相比.
- 每日使用的塔达拉菲尔在12周内也显著减少了抑郁和焦虑症状 (P <0.05).
- 按需的塔达拉菲尔对PME最有效,在66.7%的ED病例中存在.
结论:
- 每日使用的塔达拉菲尔在ED治疗中比按需使用的塔达拉菲尔或西尔德纳菲尔更有效,特别是在有情绪症状的患者中.
- 在ED中PME很常见,对按需的Tadalafil反应最好.
- 塔达拉菲尔在所有评估领域都表现出优于西尔德纳菲尔的优势.
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