有机污染物和2型糖尿病的风险:系统审查和元分析
Yousif M Hydoub1, Ricardo Loor-Torres2, Abdul Qadeer3
1Department of Cardiac Sciences, Sheikh Khalifa Medical City, Abu Dhabi, United Arab Emirates.
Mayo Clinic proceedings. Innovations, quality & outcomes
|January 8, 2026
概括
暴露于各种有机污染物 (OPs) 与患2型糖尿病 (T2D) 的风险增加有关. 需要进一步的研究来确定公共卫生指南的安全暴露水平.
科学领域:
- 环境健康 环境健康
- 内分泌学 在内分泌学.
- 毒理学 毒理学 毒理学
背景情况:
- 有机污染物 (OP) 是普遍存在的环境污染物.
- 2型糖尿病 (T2D) 是一个日益严重的全球健康问题.
- 运营商和T2D风险之间的潜在联系需要彻底调查.
研究的目的:
- 系统地评估不同有机污染物 (OP) 的血清度与患2型糖尿病 (T2D) 的风险之间的关联.
主要方法:
- 在主要的科学数据库 (Medline,Embase,Scopus,Web of Science,Cochrane Central) 进行了全面的文献搜索,截至2024年3月.
- 包括的研究报告了OP血清水平与T2D风险之间的调整或未调整的关联,不包括1型糖尿病和100例T2D病例以下的研究.
- 使用随机效应模型计算了聚合风险估计,根据性别和度进行了偏差风险评估和分层分析.
主要成果:
- 这项元分析包括了44项与54,967名参与者的研究,检查了83个单个和38个组合OP.
- 在12个OP类中,有10个与T2D风险有显著关联. 多化二子-p- furan 呈现出最高的关联 (OR,2.54).
- 特定的污染物,如多双 (PCB) 和二二三乙 (DDT) 显示出显著的关联,性别之间观察到的差异. 有机化农药显示出特别高的风险 (OR,4.35).
结论:
- 几种有机污染物与2型糖尿病的风险显著增加有关.
- 未来的研究应该专注于确定OPs的临界度值,这些值会引发T2D风险增加.
- 结果可以为T2D查和有机污染物监管的公共卫生战略提供信息.
相关概念视频
Diabetes Mellitus: Type 2 and Gestational
4.3K
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
4.3K
Pathophysiology of Diabetes
3.1K
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
3.1K
Carbohydrate Metabolism
13.8K
Carbohydrates are polymers composed of molecules containing atoms of carbon, hydrogen and oxygen. One gram of carbohydrate can provide four kilo-calories of energy, which makes it the most efficient instant energy source.
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
13.8K
Diabetes Mellitus: Overview and Type I Subtype
4.8K
Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
4.8K
Diabetes: Symptoms, Diagnosis, and Complications
2.0K
For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
2.0K
Psychoneuroimmunology: Diabetes and Cancer
432
Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
432


