相关实验视频

Updated: Jan 13, 2026

Fragility Assessment of Bovine Cortical Bone Using Scratch Tests
08:36

Fragility Assessment of Bovine Cortical Bone Using Scratch Tests

Published on: November 30, 2017

9.9K

先进的糖化最终产品添加物改变了骨原蛋白网络和人类皮质骨骨折抵抗力

Daniel Y Dapaah1, Shoutaro Arakawa2, Gwennyth A Carroll3

  • 1Department of Systems Design Engineering, University of Waterloo, Waterloo, ON, N2L 3G1, Canada.

JBMR plus
|January 8, 2026
PubMed
概括

先进的糖化最终产品 (AGEs) 在2型糖尿病和CKD中破坏骨原蛋白交叉连接,增加骨折风险. 非交叉连接的AGE附加物,而不是托西丁,是减少骨强度的关键贡献者.

关键词:
在CKD中,它是最好的.先进的糖化最终产品添加物.原蛋白网络连接性的连接.皮质骨骨折的性 皮质骨折的性lysyl氧化酶酶的酶交叉链接2 型糖尿病 2 型糖尿病

更多相关视频

Imaging of the Microstructural Failure Mechanism in the Human Hip08:43

Imaging of the Microstructural Failure Mechanism in the Human Hip

Published on: September 29, 2023

1.3K
Author Spotlight: Enhancing Bone Regeneration with Vascularized Artificial Cartilage Integration06:05

Author Spotlight: Enhancing Bone Regeneration with Vascularized Artificial Cartilage Integration

Published on: July 14, 2023

1.6K

相关概念视频

Bone Disorders01:29

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
5.0K
Bone Remodeling01:40

Bone Remodeling

Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
40.2K
The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
3.2K
Fractures: Bone Repair01:27

Fractures: Bone Repair

Treatment for a fracture is based on the type of break, the bone affected, and the patient's age.
Minor fractures with no bone displacement are treated by immobilizing the fractured bone using a cast or splint. However, in the case of fractures with displaced bones, the broken bones are repositioned before immobilization to ensure successful healing without deformation and loss of function. The realignment of fractured bone ends is performed through a process called reduction. If the...
5.0K
The Bone Matrix01:18

The Bone Matrix

Bone contains a relatively small number of cells entrenched in a matrix of collagen fibers that provide an adherent surface for inorganic salt crystals. Both components of the matrix, organic and inorganic, contribute to the unusual properties of bone. Without collagen, bones would be brittle and shatter easily. Without mineral crystals, bones would flex and provide little support. This can be observed by an experiment: when the minerals of a bone are dissolved by soaking the bone in...
5.4K
Essential Minerals for Bone Health01:31

Essential Minerals for Bone Health

The minerals contained in all of the food we consume are essential for our organ systems. However, certain essential minerals, such as calcium, phosphorus, magnesium, manganese, and fluoride, largely affect bone health.
Calcium and Phosphorus
Calcium is a critical component of bones, especially in the form of calcium phosphate and calcium carbonate. Since the body cannot make calcium, it must be obtained from the diet. However, calcium cannot be absorbed from the small intestine without...
5.9K