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Updated: Jan 13, 2026

Adenoviral Gene Therapy for Diabetic Keratopathy: Effects on Wound Healing and Stem Cell Marker Expression in Human Organ-cultured Corneas and Limbal Epithelial Cells
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Adenoviral Gene Therapy for Diabetic Keratopathy: Effects on Wound Healing and Stem Cell Marker Expression in Human Organ-cultured Corneas and Limbal Epithelial Cells

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复合型血栓模块域1通过抑制HMGB1和NLRP3炎症酶的产生促进糖尿病角质伤口愈合

Kuan-Ying Chen1, I-Chen Peng2, Hua-Lin Wu3

  • 1Education Center, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan, ncku.edu.tw.

Mediators of inflammation
|January 8, 2026
PubMed
概括

重组血栓模块素域1 (rTMD1) 通过减少炎症,加速糖尿病角膜伤口愈合. 这种蛋白质在治疗糖尿病角质炎方面表现有前途.

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Clot Retraction and Fibrinolysis01:16

Clot Retraction and Fibrinolysis

After a fibrin clot is formed, the next step is clot retraction, a vital process facilitated by platelet contractile proteins, such as actin and myosin. These proteins pull the fibrin strands closer together and condense the clot. This action reduces the size of the clot, creating a smaller, denser structure that effectively seals off the damaged vessel. Clot retraction consolidates the clot and helps with wound healing by bringing the edges of the damaged blood vessel closer together.
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