移植患者的症状负担和患者报告的结果:来自TransplantLines生物库和队列研究的结果
Niels L Riemersma1, Tim J Knobbe1, Daan Kremer1
1University of Groningen, University Medical Center Groningen, Department of Internal Medicine, Division of Nephrology, Groningen, The Netherlands.
Kidney medicine
|January 8, 2026
概括
接受移植的接受者通常会感到疲劳和缺乏能量,经历月经问题和阳的严重痛苦. 解决症状负担对于改善患者的治疗结果和移植后的生活质量至关重要.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學.
- 移植免疫学 移植免疫学
- 患者报告的结果.
背景情况:
- 移植接受者 (KTR) 经常面临许多影响其健康相关生活质量的症状 (HRQoL).
- 了解症状发病率,痛苦和促成因素对于改善KTR护理至关重要.
研究的目的:
- 识别KTR中最常见和最令人痛苦的症状.
- 探索症状负担的决定因素.
- 检查症状负担和患者报告的结果之间的关联.
主要方法:
- 一个横截面的,回顾性研究涉及936个稳定的KTR移植后一年.
- 使用Ridit分析评估症状,并计算症状负担得分.
- 分析了与临床变量和患者报告结果的关联.
主要成果:
- 疲劳,伤和缺乏精力是最常见的症状.
- 月经问题,阳和关节疼痛是最令人痛苦的.
- 女性性别,营养不良,环素和质子抑制剂的使用与更高的症状负担有关.
- 增加的症状负担与不坚持药物治疗,抑郁,焦虑,减少社会参与和较低的HRQoL相关.
结论:
- 症状负担显著影响KTR,疲劳和缺乏能量是普遍存在的.
- 决定因素包括女性性别,营养不良和特定药物使用.
- 解决症状负担对于改善整体患者福祉和移植后的结果至关重要.
相关概念视频
Kidney Transplant I: Introduction
333
A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
333
Kidney Transplant III: Nursing Management
307
Postoperative Nursing Management for Kidney Transplant PatientsPostoperative nursing management care includes monitoring the surgical site, encouraging early movement, and promoting lung health through breathing exercises. Nurses also administer prescribed medications like H2-blockers, such as famotidine, or proton pump inhibitors, like omeprazole, to help prevent gastrointestinal ulcers and bleeding. Fungal infections in the mouth and bladder can result from immunosuppressive and antibiotic...
307
Kidney Transplant II: Surgical Procedure
298
Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living...
298
Tissue Transplantation
888
Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
888
Chronic Kidney Disease II: Clinical Manifestations
543
Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
543
Acute Kidney Injury IV: Diagnostic Studies and Prevention
256
Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
256


