通过细胞分裂和ESRP1依赖机制,EMT诱导的干细胞和介质细胞程序可以脱
Petra den Hollander1,2, Maria Castaneda3, Suhas V Vasaikar3,4
1Department of Pathology and Laboratory Medicine, Brown University, Providence, RI, USA.
iScience
|January 8, 2026
概括
皮质到介质细胞的转变 (EMT) 驱动了干和介质细胞的特征. 在EMT期间,细胞分裂和ESRP1控制干度,这预测了癌症的不良预后.
科学领域:
- 细胞生物学 细胞生物学
- 癌症研究 癌症研究
- 发展生物学 发展生物学
背景情况:
- 表皮细胞转变为介质细胞 (EMT) 是一种过程,在这种过程中,表皮细胞获得介质细胞的特征.
- EMT与干性和介质细胞性质有关,这对癌症的发育和进展至关重要.
- 细胞分裂和EMT诱导的干性之间的相互作用尚未完全理解.
研究的目的:
- 为了研究细胞分裂在EMT驱动的干性中的作用.
- 为了确定EMT诱导的干的关键调节者.
- 确定EMT后的茎状和介质细胞特征的预后意义.
主要方法:
- 在细胞分裂或不分裂的上皮细胞中诱导EMT.
- 对茎状和介质细胞标记物的分析.
- 调查ESRP1在EMT驱动的干性中所扮演的角色.
- 分子特征与患者预后之间的相关性分析.
主要成果:
- 细胞分裂对于在EMT期间获得干性至关重要;阻断分裂产生介质细胞的特征,但不是干性.
- ESRP1是EMT驱动的干度的关键调节器,以细胞分裂依赖的方式下调.
- 过度表达ESRP1会抑制干的增加,而不会影响间酶体的特性.
- 受到EMT诱导的干部,而不是介质细胞的特征,与预后不佳相关.
- 具有干细胞的癌细胞表现出介质细胞性质,但相反的情况并不总是如此.
结论:
- 由EMT驱动的干性受细胞分裂和ESRP1.1的调节.
- 由EMT诱导的干性程序,而不是介质细胞程序,预测了患者的不良结果.
- 在EMT期间了解干部和介质细胞程序的脱提供了治疗目标.
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