跨神经系统疾病的开环和闭环神经调节 面向个性化大脑刺激:叙述性综述
Meet Popatbhai Kachhadia1, Imad Sibhai2, Rushi Vaghela3
1Neurology, Florida Atlantic University Charles E. Schmidt College of Medicine, Boca Raton, USA.
Cureus
|January 8, 2026
概括
闭环深脑刺激 (DBS) 为神经系统疾病提供了适应性治疗,改善了症状控制和设备效率. 对生物标志物和算法的进一步研究是个性化神经调节的关键.
科学领域:
- 神经学和精神病学 精神病学
- 生物医学工程 生物医学工程
- 神经科学是一个神经科学.
背景情况:
- 神经和精神疾病导致全球严重的残疾.
- 深度大脑刺激 (DBS) 是药物耐药病例的关键治疗方法.
- 传统的开环DBS具有诸如副作用和不灵活性等局限性.
研究的目的:
- 审查神经和精神疾病的开放和闭环神经调节.
- 为了比较两种DBS方法的优点和局限性.
- 突出适应算法和生物标志物在个性化神经调节中的作用.
主要方法:
- 叙事审查综合现有证据.
- 对比优势,局限性和翻译挑战的分析.
- 强调生物标志物,自适应算法和机器学习.
主要成果:
- 闭环DBS使用实时生物标志物调整刺激,改善症状控制.
- 闭环系统减少了刺激时间,提高了设备的寿命.
- 结果因生物标志物,算法和方法的差异而有所不同.
结论:
- 闭环刺激代表了向神经调节中精准医学的范式转变.
- 强大的生物标志物,预测算法和临床框架对于广泛采用至关重要.
- 进一步整合至关重要,以实现闭环神经调节的全部潜力.
相关概念视频
Neural Regulation
34.8K
Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
34.8K
Ligand-gated Ion Channels
11.4K
Ligand-gated ion channels are transmembrane proteins with a channel for ions to pass through and a binding site for a ligand. The channel opens only when a ligand attaches to the binding site.
Three Subfamilies of Ligand-gated Ion Channels
Ligand-gated ion channels fall into three subfamilies. The 'Cys-loop' includes the nicotinic acetylcholine receptors, γ-aminobutyric acid (GABA), glycine, and 5-hydroxytryptamine receptors. The second one is the 'Pore-loop' channels that...
Three Subfamilies of Ligand-gated Ion Channels
Ligand-gated ion channels fall into three subfamilies. The 'Cys-loop' includes the nicotinic acetylcholine receptors, γ-aminobutyric acid (GABA), glycine, and 5-hydroxytryptamine receptors. The second one is the 'Pore-loop' channels that...
11.4K
Neuroplasticity
2.6K
Neuroplasticity reflects the brain's remarkable capacity to adapt and evolve, responding dynamically to learning, experiences, or injury by reorganizing its neural circuitry. This reorganization involves creating new neural connections and refining old ones through a series of biological processes that contribute to the brain's lifelong development and adaptability.
2.6K


