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西太平洋地区的气候变化和抗微生物耐药性:混合方法系统分析

Lianping Yang^1,2, Zishu Ma¹, Fanqian Meng¹

¹School of Public Health, Sun Yat-sen University, Guangzhou, China.

The Lancet regional health. Western Pacific

|January 8, 2026

概括

气候变化加剧了西太平洋地区的抗菌素耐药性 (AMR). 气温上升与抗药性耐药性死亡率的增加相关,突显了对综合监测和有弹性的卫生系统的迫切需要.

科学领域:

公共卫生公共卫生
环境科学环境科学
传染性疾病传染性疾病

背景情况:

抗菌素耐药性 (AMR) 和气候变化是全球卫生面临的关键挑战.
西太平洋地区在气候和AMR的交叉点面临着独特的脆弱性.
关于该地区特定的气候-AMR联系的证据有限.

研究的目的:

系统地调查西太平洋地区气候变化和抗菌耐药性之间的关系.
提供有关气候驱动的AMR趋势和死亡率的定量证据.
确定关键驱动因素,并为区域公共卫生战略提供信息.

主要方法:

采用了三阶段混合方法系统分析.
包括叙事审查,系统文献审查 (2000-2025) 和纵向数据集的定量分析.
根据气候和社会经济因素,回归分析模拟了由AMR引起的死亡.

主要成果:

温度的上升加快了细菌的生长和耐药性,并增加了滥用抗生素.
高温与抗生素耐药性基因 (ARG) 的临床耐药性增加和环境传播有关.
温度上升1°C与CRAB和CRPA的AMR死亡率较高相关;社会经济因素显示出不同的影响.

结论:

气候条件和社会经济脆弱性共同影响西太平洋地区的抗菌耐药性风险.
预计的极端天气事件可能会给医疗保健系统带来压力,并加剧抗生素的滥用.
加强适应气候变化的卫生系统和集成的抗菌素耐药性气候监测是关键的区域优先事项.

关键词:

抗微生物耐药性抗微生物耐药性气候变化气候变化气候变化适应气候变化的健康系统.脆弱性易受伤害脆弱性

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