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高咖啡因暴露对未成熟雌性大鼠青春期纵向骨生长的影响

Jihyun Keum¹, Yuri Choi², Ki-Young Ryu¹

¹Department of Obstetrics and Gynecology, College of Medicine, Hanyang University, 222, Wangsimni-ro, Seongdong-gu, Seoul, Republic of Korea.

Toxicological research

|January 8, 2026

概括

在雌性老鼠青春期暴露于咖啡因会减少骨生长和矿物质含量. 它还增加了雌激素水平和改变了生长板的特征,表明骨成熟受损.

科学领域:

内分泌学在内分泌学.
骨生物学骨生物学骨生物学
药理学药理学是指药理学的学科.

背景情况:

青春期对于骨发育至关重要.
咖啡因对女性青春期骨生长的影响还未得到充分研究.
以前的研究主要使用男性模型,忽视了雌激素的作用.

研究的目的:

研究青春期咖啡因暴露对雌性大鼠骨生长的影响.
评估咖啡因对骨矿物质含量,密度和生长板组织学的影响.
为了确定咖啡因是否会改变女性青春期发育期间的雌激素水平.

主要方法:

未成熟的雌性Sprague-Dawley大鼠被给予咖啡因 (120和180毫克/公斤/天) 或安慰剂4周或8周.
测量包括体重,腿骨的长度和重量,骨矿物质含量和密度.
分析了血清雌激醇水平和近端叶生长板组织形态测量.

主要成果:

咖啡因暴露减少了体重,腿骨的长度和体重,这取决于剂量和时间.
骨矿物质含量下降,骨矿物质密度在4周后受到影响.
观察到血清雌激素水平升高和生长板高度增加,骨形成减少和海绵状高度下降.

结论:

在女性青春期暴露于咖啡因会对骨生长和成熟产生负面影响.
研究结果表明,咖啡因会干扰骨矿化和骨质细胞活性.
需要进行进一步的研究,以评估这些影响在戒掉咖啡因后的持续性.

关键词:

咖啡因咖啡因是一种咖啡因.一个女人,一个女人.长骨的长骨是一个很长的骨头.青春期青春期青春期鼠标鼠标鼠标鼠标

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