相关实验视频
Updated: Jan 13, 2026

09:26
Quantification of Orofacial Phenotypes in Xenopus
Published on: November 6, 2014
10.2K
在多民族队列中非综合性裂的侧面性和完整性模式
Christina Spencer1, Ligiane A Machado-Paula1, Fang Qian1
1University of Iowa.
medRxiv : the preprint server for health sciences
|January 8, 2026
概括
在不对称的双边裂唇中,左侧通常是完整的. 虽然单边裂没有表现出对完整性的偏好,但种族,种族和性别显著影响了裂严重程度的模式.
科学领域:
- 头骨脸部异常情况
- 遗传学和发育生物学
- 公共卫生 公共卫生
背景情况:
- 面腔裂,包括带有或没有口腔裂的裂唇 (NSCL/P),其严重程度从部分厚度到完全厚度各不相同.
- 了解裂完整性的模式对于诊断和治疗规划至关重要.
研究的目的:
- 评估非综合症不对称的双边和单边裂口唇与或没有裂口 (NSCL/P) 的裂口完整性的侧面偏好.
- 分析裂完整性,性别,种族和种族在不同的人口之间的关联.
主要方法:
- 分析了来自四个多民族群体 (北美/南美,亚洲,非洲) 的3,561名NSCL/P患者.
- 使用奇方位或费舍尔精确测试来评估裂完整性,性别,种族和种族之间的关联.
- 包括具有关于裂类型和完整性的完整信息的患者.
主要成果:
- 在不对称的双边病例中,左侧裂完整的发生率明显高于右侧裂完整的发生率 (73.7%对26.3%;p<0.001).
- 在对称的双边和单边案件中,西班牙裔的完成率高于非西班牙裔.
- 与亚洲人,黑人或其他种族群体相比,高加索人具有较低的完整率 (p<0.001),女性呈现的裂比男性更完整 (p=0.003).
结论:
- 在NSCL/P中,左侧更频繁地完整,双边不对称.
- 单侧裂的完整性表明没有侧面偏好,与左侧裂的整体较高发病率相反.
- 种族,种族和裂严重程度的模式之间存在显著的关联.
相关概念视频
Lateralization
960
Brain lateralization refers to the division of mental processes and functions between the two hemispheres of the brain, a phenomenon that optimizes neural efficiency and underpins complex abilities in humans. This specialization allows each hemisphere to perform tasks where it has a comparative advantage, facilitating more refined cognitive capabilities across different domains.
960
Sutures of the Skull
10.1K
The human skull is composed of several bones that come together to protect the brain and support the structures of the face. The junctions where these bones meet are called sutures.
Sutures are immobile joints between adjacent bones of the skull. The narrow gap between the bones is filled with dense, fibrous connective tissue that unites the bones. The long sutures located between the skull bones are not straight but instead follow irregular, tightly twisting paths. These twisting lines tightly...
Sutures are immobile joints between adjacent bones of the skull. The narrow gap between the bones is filled with dense, fibrous connective tissue that unites the bones. The long sutures located between the skull bones are not straight but instead follow irregular, tightly twisting paths. These twisting lines tightly...
10.1K
Pedigree Analysis
88.8K
Overview
88.8K
Pleiotropy
43.2K
Pleiotropy is the phenomenon in which a single gene impacts multiple, seemingly unrelated phenotypic traits. For example, defects in the SOX10 gene cause Waardenburg Syndrome Type 4, or WS4, which can cause defects in pigmentation, hearing impairments, and an absence of intestinal contractions necessary for elimination. This diversity of phenotypes results from the expression pattern of SOX10 in early embryonic and fetal development. SOX10 is found in neural crest cells that form melanocytes,...
43.2K
Structural Classification of Joints
6.9K
Joints, also known as articulations, are classified based on their structural characteristics, i.e., based on whether the articulating surfaces of the adjacent bones are directly connected by fibrous connective tissue or cartilage, or whether the articulating surfaces contact each other within a fluid-filled joint cavity. These differences serve to divide the joints of the body into three structural classifications.
A fibrous joint is where the adjacent bones are united by fibrous connective...
A fibrous joint is where the adjacent bones are united by fibrous connective...
6.9K
Genomic Imprinting and Inheritance
36.8K
Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
36.8K

