在一个儿科B-ALL患者的linesolid-resistant和vancomycin-resistantEnterococcus faecium尿液分离物中
Emma Seevak1, Tanvi S Sharma1,2, Alaric W D'Souza1,2,3
1Harvard Medical School, Boston, Massachusetts, USA.
ASM case reports
|January 8, 2026
概括
抗米素耐药Enterococcus faecium (VRE) 中的林氏素耐药性对治疗提出了挑战,特别是在免疫功能低下的患者中. 这一案例强调了需要精确的敏感性测试来指导VRE感染的治疗.
科学领域:
- 传染性疾病 传染性疾病
- 抗微生物耐药性 抗微生物耐药性
- 临床微生物学 临床微生物学
背景情况:
- 耐万科米辛的菌 (Enterococcus faecium,简称VRE) 是与医疗相关的感染的重要原因之一.
- 利尼佐利德是治疗耐药格拉姆阳性细菌的关键抗生素,包括VRE.
- 在VRE中出现的linezolid耐药性对治疗选择构成严重威胁,特别是在脆弱人群中.
研究的目的:
- 报告儿科病人的linezolid耐药VRE感染病例.
- 要突出与检测VRE中的linezolid耐药性相关的诊断困难.
- 强调准确的抗菌素敏感性测试对于指导VRE治疗的重要性.
主要方法:
- 一个16岁的女性患有B细胞急性淋巴细胞白血病的病例报告.
- 使用多个抗微生物敏感性测试平台对VRE分离物的评估.
- 对线化物和氨基醇的最低抑制度的监测.
主要成果:
- 由于VRE.患者患上了尿路感染.
- 在不同测试平台上观察到不一致的linezolid敏感性结果.
- 增加线化物和氨基醇的最小抑制度表明了通过核糖体标介导的耐药性.
- 达普托米辛治疗最终被要求用于对线化物耐药的VRE.
结论:
- 在VRE中检测新兴的linezolid耐药性是诊断上具有挑战性的.
- 准确和及时的敏感性测试对于有效的VRE管理至关重要.
- 需要改善对确认诊断的准入,以指导在怀疑linezolid耐药性时的治疗.
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