身体活动和基于缺陷的脆弱性对老年人全因死亡率的相互作用:对五个基于人口的队列进行前性研究
Zheng Zhu1,2, Xu Zhou1,2, Mingling Chen1,2
1Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
The Lancet regional health. Western Pacific
|January 8, 2026
概括
定期体育活动显著降低了脆弱的老年人死亡风险. 这种益处在脆弱个体中比强壮个体更为明显,这凸显了运动对健康衰老的重要性.
科学领域:
- 老年学是指老年学的学科.
- 公共卫生 公共卫生
- 流行病学 流行病学
背景情况:
- 在脆弱的老年人中,休时间的体力活动与死亡风险之间的关系尚不清楚.
- 脆弱性是老年人群死亡率的重要预测因素.
- 了解身体活动等潜在的修饰因素对于公共卫生干预至关重要.
研究的目的:
- 调查休时间的体力活动是否会改变老年人脆弱性和全因死亡率之间的关联.
- 分析身体活动水平和脆弱状态之间的相互作用影响,在多样化,大规模队列的死亡风险.
主要方法:
- 利用考克斯的比例危险模型分析了来自五个全国代表性队列 (SHARE,CHARLS,HRS,ELSA,MHAS) 的数据,涉及超过93,000名参与者.
- 根据各种健康缺陷,使用缺陷积累模型 (坚固,易受伤害,易受伤害) 进行分类的脆弱状态.
- 身体活动被归类为常规 (符合世卫组织建议) 或不活跃.
主要成果:
- 在所有五个队伍中都观察到身体活动和虚弱与全因死亡率之间的一致相互作用 (P相互作用 ≤0.036).
- 在聚合分析中,虚弱与不活跃个体的死亡风险更高 (HR:3.72),而不是经常活跃的个体 (HR:2.40).
- 定期体育活动的生存益处在脆弱的参与者中更为明显 (HR:0.56),而不是在强壮的参与者中 (HR:0.80).
结论:
- 定期体育活动显著减轻了与老年人虚弱相关的死亡风险增加.
- 虚弱的老年人可能会从参与定期体育活动中获得更大的生存益处,而不是他们的强壮对手.
- 研究结果支持促进体育活动作为改善老龄人口寿命和健康结果的关键策略.
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