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在使用CMR特征追踪检测高血压HFpEF检测中,心房应变优于心室应变

Zhen Wang¹, Yuncheng Li¹, Yong Cheng¹

¹Department of Radiology, The First Affiliated Hospital of Anhui Medical University; Research Center of Clinical Medical Imaging; Anhui Province Clinical Image Quality Control Center, Hefei, China (Z.W., Y.L., Y.C., Y.Y., X.L.).

Hypertension (Dallas, Tex. : 1979)

|January 8, 2026

概括

与左心室应变相比,左心室应变成像,特别是储应变 (εs),在高血压患者中检测心力衰竭与保留射出分数 (HFpEF) 的优异标志物. 这突出了LA菌株的突出.

科学领域:

心脏病学心脏病学
医疗成像医学成像
生物标志物生物标志物

背景情况:

保存喷射分数 (HFpEF) 的心力衰竭约占心力衰竭病例的50%.
高血压经常与HFpEF共存,使诊断和管理复杂化.
虽然应变成像有助于检测亚临床心脏功能障碍,但左心房 (LA) 与左心室 (LV) 应变在高血压HFpEF中的比较诊断实用性仍然不清楚.

研究的目的:

为了比较LA菌株与LV菌株的诊断价值,用于识别高血压患者的HFpEF.
为了确定最佳的心脏磁共振 (CMR) 功能,用于高血压背景下检测HFpEF的跟踪衍生的应变参数.
评估不同LA和LV菌株参数的歧视性表现.

主要方法:

一项追溯性研究涉及191名参与者:71名HFpEF和高血压患者 (HFpEF-HTN),60名基本高血压患者和60名对照患者.
用心脏MR特征追踪来量化LV的全球菌株和菌株率.
测量了LA水库 (εs),管道 (εe) 和增压 (εa) 的应变及其相应的应变率.

主要成果:

所有LA菌株参数都显示了从对照对象到高血压患者到HFpEF-HTN患者的渐进性损伤 (P<0.05).
与对照组相比,HFpEF-HTN减少了LV全球菌株,而高血压仅显示了全球纵向菌株的减少 (P<0.05).
拉氏菌株参数表现出优于LV参数的区分性能, εs是HFpEF-HTN与高血压 (AUC=0.802) 和高血压与对照组 (AUC=0.892) 的最佳区分因子, εe是高血压与对照组 (AUC=0.892) 的最佳区分因子.

结论:

在区分高血压HFpEF方面,LA菌株参数,特别是储菌株 (εs),在区分高血压HFpEF方面,与LV菌株相比,提供更好的诊断性能.
这些发现表明,LA菌株可以作为检测高血压HFpEF的敏感成像生物标志物.
在临床实施LA菌株分析用于HFpEF诊断之前,建议进一步进行前性验证.

关键词:

在曲线下面的面积.基本高血压是什么意思全球纵向菌株全球纵向菌株心脏衰竭是因为心脏衰竭.这种高血压,高血压.

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