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Regression toward the mean (“RTM”) is a phenomenon in which extremely high or low values—for example, and individual’s blood pressure at a particular moment—appear closer to a group’s average upon remeasuring. Although this statistical peculiarity is the result of random error and chance, it has been problematic across various medical, scientific, financial and psychological applications. In particular, RTM, if not taken into account, can interfere when...
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评估随机多捐赠者聚合对捐赠人母乳营养变量的影响,使用计算机建模.

R Mitchell Smith1, Scott Richter1,2, Esther F Iwayemi3

  • 1Department of Mathematics and Statistics, University of North Carolina Greensboro, Greensboro, North Carolina, USA.

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概括
此摘要是机器生成的。

将更多的捐赠者与捐赠人母乳 (DHM) 结合在一起,可以减少宏观营养素的变化. 然而,即使每池有10个捐赠者,也无法确保DHM中关键微量营养素的稳定水平.

关键词:
捐赠者牛奶提供者牛奶银行 牛奶银行矿物质是矿物质中的一种.营养 营养 营养 营养预产期前的时间.维生素 维生素 维生素 是一种

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科学领域:

  • 人类牛奶银行和婴儿营养
  • 营养生物化学和分析.
  • 生物可用性和营养稳定性

背景情况:

  • 捐赠母乳 (DHM) 的成分,特别是蛋白质和脂肪,表现出显著的变化.
  • 这种变异性受到为牛奶池贡献的独特捐赠者的数量的影响.
  • 了解聚合效应对于优化易受伤害的婴儿的DHM营养质量至关重要.

研究的目的:

  • 描述捐赠池大小 (2-10个捐赠者) 对DHM巨量营养素,维生素和矿物质变异性的影响.
  • 确定所需的最低捐赠者数量,以实现对真正蛋白质,脂肪和DSLNT的80%目标合规.
  • 通过营养不平等指数 (NII) 评估营养变异性.

主要方法:

  • 蒙特卡洛模拟模拟了供体生命周期体积和牛奶库生产约束.
  • 用营养不平等指数 (NII) 量化营养变异性:90至10百分点的比率.
  • 模拟分析了宏观营养素,维生素,矿物质和生物活性因素的聚合效应.

主要成果:

  • 将2-10个捐赠者聚集在一起,可以比大多数维生素和矿物质更有效地降低DHM宏观营养素的变化.
  • 对真正的蛋白质,脂肪和DSLNT的预定义目标在组合场景中无法持续实现.
  • 乳糖 (<1.1) 和3个以上的捐赠者,脂肪/蛋白质 (<1.3) 和5个以上的捐赠者稳定了NII.
  • 微量营养素 (如,铁,B族维生素) 的高NII (>1.5) 持续存在,即使有10个捐赠者.

结论:

  • 在DHM池中增加捐助者数量可以减轻宏观营养素的变化,但对微量营养素的一致性的影响有限.
  • 为了达到DHM中某些成分的精确营养目标,需要仔细选择供体和潜在的更大的池大小.
  • 微量营养素的变化仍然是DHM加工中的一个重大挑战,需要进一步的研究和潜在的强化策略.