免疫检查点抑制剂治疗中与免疫相关的不良事件和预后之间的关联:图书统计和视觉分析
Jun Zhao1, Xianghua Quan1, Yu Liang1
1Department of Pharmacy, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.
Human vaccines & immunotherapeutics
|January 8, 2026
概括
免疫相关不良事件 (irAEs) 与癌症免疫治疗后患者预后之间的联系尚不清楚. 这种文献计量分析确定了目前的研究热点和irAEs的未来趋势和预后,以指导进一步的研究.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 图书统计学 图书统计学
背景情况:
- 越来越多地使用癌症免疫疗法导致免疫相关不良事件 (irAEs) 的增加.
- 在接受免疫治疗的患者中,irrAEs的预后意义仍然是争论的主题,需要进一步调查.
研究的目的:
- 进行关于irAEs与预后之间关系的研究的文献分析.
- 确定当前的研究热点和该领域的未来趋势.
主要方法:
- 从Web of Science数据库中对2007年1月至2023年12月期间发表的文章和评论进行图书统计分析.
- 使用的关键词:免疫检查点抑制剂 (ICI),与免疫相关的不良事件,预后.
- 使用CiteSpace,VOSviewer和Carrots2软件进行分析,检查作者,机构,国家,关键词和引用文献.
主要成果:
- 包括724篇文章,主要来自中国,美国和日本.
- 黑色素瘤,小细胞肺癌和细胞癌是研究最多的瘤类型.
- 关键的研究主题包括 Myasthenia gravis,神经毒性,肝损伤,头部和部不良事件,大肠炎和皮肤不良事件.
结论:
- 本研究提供了关于irAEs和预后的当前研究格局的全面概述.
- 未来的研究热点可能包括组合疗法,预测生物标志物,患者并发症,葡萄糖皮质类药物,预后指标和ICI再挑战,有助于开发个性化医疗策略.
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