Moringa oleifera可以改善小肠中酸引起的氧化损伤
Melis Coremen1, Onur Ertik2, Umar Faruk Magaji3
1Faculty of Science, Department of Biology, Istanbul University, Istanbul, Türkiye.
Archives of physiology and biochemistry
|January 8, 2026
概括
莫林加油提取物保护了老鼠免受瓦尔酸引起的小肠损伤. 该研究发现,Moringa oleifera提取物减轻了氧化应激和肠道结构损伤.
科学领域:
- 药理学 药理学是指药理学的学科.
- 毒理学 毒理学 毒理学
- 胃肠病学 胃肠病学
背景情况:
- 众所周知,酸 (VPA) 会引起胃肠道毒性.
- 氧化应激在VPA引起的器官损伤中起着至关重要的作用.
- 莫林加油 (MO) 具有已知的抗氧化和抗炎性质.
研究的目的:
- 在大鼠模型中研究Moringa oleifera提取物对酸诱导的小肠损伤的保护作用.
- 评估VPA和MO治疗后小肠中的生化和组织学变化.
主要方法:
- 46只雌性Sprague-Dawley大鼠被分为四组:对照组,MO提取物,VPA和VPA+MO提取物.
- 治疗方法是口服的,持续了15天.
- 进行了氧化应激的生物化学分析,分子对接研究,免疫组织化学和组织学检查.
主要成果:
- 在接受VPA治疗的老鼠中,Moringa oleifera提取物显著减轻了氧化应激的生化标志物.
- 分子对接建议MO叶中的生物活性化合物抑制与氧化压力相关的酶.
- 组织学分析显示,MO治疗减轻了VPA诱导的小肠结构损伤,而不会改变Nrf2表达.
结论:
- 在大鼠中,Moringa oleifera提取物表现出显著的保护性和抗氧化作用,防止酸诱导的小肠损伤.
- MO提取物可以作为一种潜在的治疗剂,以减轻VPA引起的胃肠道毒性.
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