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在真菌细菌感染中,肠肺轴和微生物组的改变:从致病源到治疗潜力

Kimin Kang¹, Joong-Yub Kim^2,3, Jae-Joon Yim⁴

¹Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Republic of Korea.

|January 8, 2026

概括

菌根性肺部疾病与肠道和肺部细菌失衡有关. 恢复这种微生物组平衡可能为结核病和其他菌根性肺部疾病提供新的治疗方法.

科学领域:

微生物学微生物学
免疫学免疫学免疫学
肺部病理学肺部病理学

背景情况:

菌根性肺病,包括结核病 (TB) 和非结核性菌根性肺病 (NTM-PD),受宿主免疫和肠肺轴 (GLA) 的影响.
菌根菌感染和抗生素治疗破坏了肠道和肺部的微生物群,导致了失生症.
这种失生症会影响免疫反应,上皮质完整性和炎症,影响疾病的进展.

研究的目的:

审查目前的证据,将微生物组失生症与真菌细菌病原性联系起来.
突出针对微生物组的干预措施作为肺部菌根病的潜在治疗策略.

主要方法:

文献综述整合了关于肠肺轴和真菌细菌疾病的当前证据.
对研究结核病和NTM-PD患者微生物组变化的研究分析.
评估微生物组调节疗法作为辅助治疗.

主要成果:

菌根菌感染和疗法通过GLA诱导肠道和呼吸道失调.
失生症的特点是微生物多样性减少,上皮质防御受损,免疫调节发生改变.
特定的微生物模式,如SCFA产生的种群枯竭和促炎性厌氧丰富,与结核病和NTM-PD有关.
微生物组的改变会影响治疗反应和疾病复发.

结论:

微生物组失生症是mycobacterial肺部疾病的发病的一个关键因素.
通过诸如益生菌或饮食变化等干预措施准微生物组显示出作为辅助疗法的希望.
对基于微生物组的策略的进一步研究可能会导致对肺部菌根病的新治疗方法.

关键词:

肠肺轴肠肺轴肠肺轴这种疾病叫做dysbiosis.微生物组是一个微生物组.没有结核的真菌菌.精准医学是一门精准医学.短链脂肪酸短链脂肪酸结核病是一种肺结核病.

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