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轻度缺血性中风患者中 Carotid 动脉样硬化和中风后认知障碍之间的关联:一项前性队列研究

GuanHua Nie¹, ZhiHong Wei², Zhan Su¹

¹Department of Neurology, The First Hospital of Jilin University, Changchun, China.

CNS neuroscience & therapeutics

|January 8, 2026

概括

冠状动脉斑块负担和严重的冠状动脉狭窄与轻度急性缺血性中风患者的中风后认知障碍 (PSCI) 有关. 冠状动脉超声波有助于早期的PSCI风险识别.

科学领域:

神经学神经学
心脏病学心脏病学
老年学是一门学科.

背景情况:

脑卒中后认知障碍 (PSCI) 是一种常见的并发症,影响中风幸存者的康复.
早期识别有风险的个体对于有效的认知康复至关重要.

研究的目的:

在轻度急性缺血性中风 (AIS) 患者中调查动脉动脉样硬化指标 (斑块负担,狭窄) 和PSCI之间的关联.
评估动脉超声波作为一种具有成本效益的工具来识别PSCI风险.

主要方法:

在发病7天内对181名轻度AIS患者进行前性队列研究.
收集了基线人口统计数据,临床数据和带超声波参数.
在6个月后使用蒙特利尔认知评估 (MoCA) 评估PSCI;通过后勤回归和ROC曲线分析预测因素.

主要成果:

41.4%的参与者在6个月后出现了PSCI.
冠状动脉斑块负担 (Crouse分数) 和严重的冠状动脉狭窄是PSCI的独立预测因素.
结合临床和超声数据的多变量模型显示出强大的预测准确性 (AUC=0.818).

结论:

冠状动脉斑块负担和严重狭窄症独立地与轻度AIS的PSCI发展有关.
带超声波,与临床因素相结合,为早期PSCI风险分层提供了一种实用的方法.

关键词:

冠状动脉斑块克劳斯得分冠状动脉斑块克劳斯得分常见的动脉狭窄的程度.轻度急性缺血性中风轻度急性缺血性中风脑卒中后认知障碍脑卒中后认知障碍

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