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在土耳其儿科人口中使用Cobas分析仪测试PT,INR和APTT的参考间隔
Berrak Guven1, Ismail Benice1, Bilgehan Acikgoz2
1Department of Biochemistry, Faculty of Medicine, Zonguldak Bulent Ecevit University, Zonguldak, Turkey.
Scandinavian journal of clinical and laboratory investigation
|January 8, 2026
概括
这项研究确定了在土耳其的前列血时间 (PT),国际正常化比率 (INR) 和激活的部分血栓形成时间 (APTT) 的儿科参考间隔. 使用Cobas t511分析仪的年龄分层结果有助于准确的儿科凝血诊断.
科学领域:
- 临床生物化学 临床生物化学
- 儿科血液学 儿科血液学
背景情况:
- 准确的凝血测试参考间隔 (RIs) 对儿科诊断至关重要.
- 现有的RI可能不适合多样化的儿科群体或特定的分析平台.
研究的目的:
- 建立针对儿科特异的参考间隔 (RIs) 进行前列血时间 (PT),国际正常化比率 (INR) 和激活的部分血栓塑时间 (APTT).
- 在土耳其儿科队列中使用Cobas t511分析仪进行可靠的凝血测试.
- 提供年龄分层的RI,以提高诊断准确度.
主要方法:
- 对1065名健康的土耳其儿科患者 (0-18岁) 的术前实验室结果的回顾性分析.
- 临床和实验室标准研究所 (CLSI) 的指导方针用于RI的确定.
- 非参数方法来定义第2.5至第97.5百分点的参考界限.
主要成果:
- 中位数 (95%的RI) 值:PT 9.0s [8.1-10.5],INR 1.02 [0.93-1.17],APTT 29.7s [24.3-35.2]. 这是一个非常重要的数字.
- 对PT,INR和APTT观察到与年龄相关的统计学上显著的差异 (p < 0.001).
- 数据成功地分为18个不同的儿科年龄组.
结论:
- 该研究在土耳其人群中使用Cobas t511分析仪提供了PT,INR和APTT的第一个儿科特异性RI.
- 年龄分层的RI提高了儿科临床实践中凝血测试的解释.
- 这些发现有助于更准确,更可靠的儿科诊断.
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