针对TRIM28-EZH2蛋白-蛋白界面与囊反应共价抑制剂:癌症治疗的计算蓝图

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Updated: Jan 13, 2026

Method for Identifying Small Molecule Inhibitors of the Protein-protein Interaction Between HCN1 and TRIP8b
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Method for Identifying Small Molecule Inhibitors of the Protein-protein Interaction Between HCN1 and TRIP8b

Published on: November 11, 2016

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Ibrahim Oluwatobi Kehinde1, Vuyisa Mzozoyana2, Sizwe J Zamisa2

  • 1Molecular Bio-Computation and Drug Design Laboratory, School of Health Sciences, University of KwaZulu-Natal, Durban, South Africa.

Chemistry & biodiversity
|January 8, 2026
PubMed
概括

异常的蛋白质-蛋白质相互作用驱动癌症. 这项研究确定了向TRIM28-EZH2复合体的共价抑制剂,这是瘤进展的关键驱动因素,提供了一种新的治疗策略.

关键词:
在 EZH2 中使用.在 TRIM2828 中,癌症 癌症 癌症 癌症 癌症同价对接对接是共价对接.同价分子分子动力学模拟.蛋白质蛋白质相互作用

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