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原及其在瘤免疫微环境中的作用:结构,功能和治疗潜力

Yinxin Zhang¹, Wenhui Wang¹, Guiyan Liu¹

¹Department of General Surgery, The Affiliated Jianhu Hospital of Xinglin College, Nantong University, Jianhu People's Hospital, 224700 Yancheng, Jiangsu, China.

Frontiers in bioscience (Landmark edition)

|January 8, 2026

概括

瘤微环境 (TME) 中的原蛋白具有双重作用,影响癌症的进展和免疫反应. 向原是一种有希望的策略,可以提高免疫治疗的有效性.

科学领域:

生物化学生物化学
免疫学免疫学免疫学
在瘤学瘤学.

背景情况:

原蛋白是细胞外基质中的主要结构蛋白,影响瘤免疫微环境 (TIME).
原蛋白的生物力学变化,如硬和纤维对齐的改变,产生迁移轨迹,并阻碍免疫细胞的透.
这些由原介导的变化强化恶性行为和免疫排除,有助于免疫疗法耐药性.

研究的目的:

在时间内审查原蛋白的结构特征,生物功能和调节途径.
探索原在瘤免疫微环境中的作用及其对癌症进展和治疗的影响.
确定针对原的潜在治疗策略,以克服免疫疗法耐药性.

主要方法:

在"时代"杂志上审查了研究原蛋白的结构和功能作用的文献评论.
对参与原蛋白作用的机械感知和机械传导途径的分析.
针对癌症治疗中的原蛋白的当前和未来临床策略的综合.

主要成果:

时间中的原变化,包括硬化和对齐,促进瘤细胞迁移,阻碍免疫细胞透.
机械感知通路转化生物机械原线索,促进恶性行为和免疫排除.
原蛋白的动态作用使其成为增强免疫治疗结果的可行的治疗标.

结论:

向与原相关的机制,如纤维化和受体信号传导,可以潜在地克服免疫疗法耐药性.
策略包括向与癌症相关的纤维细胞,酶或物理矩阵重塑以及抑制原体受体信号传递.
未来的研究应该专注于生物标志物引导治疗,结合机械生物学见解和非侵入性监测,以优化免疫疗法.

关键词:

原蛋白是一种原蛋白.细胞外矩阵重塑细胞外矩阵重塑免疫疗法免疫疗法机械感知机械感知机器治疗目标是治疗的目标.瘤免疫微环境是一个微环境.

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