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Updated: Jan 13, 2026

Models of Bone Metastasis
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十字路口的TGF-β:协调骨转移性微环境和塑造治疗边界

Khalid S Mohammad1, Fatimah Hussain Bu Izran1

  • 1Department of Anatomy, College of Medicine, Alfaisal University, 11533 Riyadh, Saudi Arabia.

Frontiers in bioscience (Landmark edition)
|January 8, 2026
PubMed
概括

转化生长因子-β (TGF-β) 驱动骨转移的恶性循环,促进瘤细胞的存活和骨的破坏. 准TGF-β和其他途径为晚期癌症治疗提供了一个有希望的策略.

关键词:
在TGFβ信号传输中.骨转移的发生.表皮 mesenchymal 过渡的转变.有针对性的治疗.瘤微环境是一个微环境.

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