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Updated: Jan 13, 2026

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试管中的化学命运:用于基于细胞的测试的生理生物动力学 (PBK) 模型

Daniela Brenner1, Kévin Bernal2, Eliška Sychrová1

  • 1RECETOX, Faculty of Science, Masaryk University, Brno, Czech Republic.

ALTEX
|January 8, 2026
PubMed
概括

一个新的计算模型,INSIGHT,通过预测细胞内的化学命运来改善体外毒理学测试. 这增强了实验设计和定量 in vitro-to-in vivo 推断,以更好地评估风险.

关键词:
贝叶斯的校准是贝叶斯的校准.双二烯是一种双二烯.在体外生物动力学.新方法方法论 (NAMs)基于生理学的动力学 (PBK) 建模.

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