肠道细菌通过将皮质醇降解为雄激素来改善抑郁症状
Xiong Wang1, Qing Wu2, Hao-Long Zeng1
1Department of Laboratory Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430030, China.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
|January 8, 2026
概括
肠道细菌可以降解压力激素皮质醇,影响抑郁症. 引入一种特定的细菌酶可以通过将皮质醇转化为雄激素来防止抑郁行为.
科学领域:
- 微生物学 微生物学
- 神经内分泌学神经内分泌学
- 代谢途径 代谢途径
背景情况:
- 人们越来越认识到肠道微生物群在调节压力激素皮质醇中的作用,但人们对其了解甚少.
- 肠道微生物组成的个体变化可能会影响皮质醇代谢和应激反应.
- 皮质醇失调与各种健康状况有关,包括抑郁症.
研究的目的:
- 研究肠道微生物群降解皮质醇的机制.
- 探索肠道微生物群对皮质醇降解和类似抑郁的行为之间的联系.
- 确定参与皮质醇代谢的特定细菌酶及其治疗潜力.
主要方法:
- 从人类便微生物群中分离和表征皮质醇降解细菌菌株.
- 在小鼠中使用肠道微生物群具有不同的皮质醇降解能力的Gavage研究.
- 对细菌酶活性及其转化产物的分子分析.
- 一种益生菌菌株 (Bacillus subtilis) 的构建,该菌株被设计成表达一种降解皮质醇的酶.
主要成果:
- 肠道微生物群表现出不同的降解皮质醇的能力.
- 具有低皮质醇降解肠道微生物群的小鼠表现出类似抑郁症的行为增加.
- 吉的 Pseudomonas aeruginosa 被分离出来,表达一种类似于des的酶,可以将皮质醇转化为雄激素.
- 这种细菌的类似于des的酶通过降解皮质醇和产生雄激素来保护小鼠免受类似于抑郁的行为.
- 工程化Bacillus subtilis表达类似于des的酶减轻了宿主中的皮质醇升高.
结论:
- 细菌的des-like酶可以降解皮质醇,并可能调节宿主应激反应.
- 皮质醇通过细菌酶转化为雄激素提供了一种改善情绪和预防抑郁的新机制.
- 通过表达类似于des的酶的工程益生菌代表了对皮质醇相关疾病和抑郁症的潜在治疗策略.
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