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持续的生长激素治疗在儿童和成年之间的过渡期对骨矿化的影响
C Bailly1,2, E Le Roux3, M Polak2,4,5
1Endocrinology and Reproductive Medicine Department, Pitié-Salpêtrière University Hospital, AP-HP, Paris, France.
Endocrine connections
|January 8, 2026
概括
在儿童持续生长激素缺乏症 (GHD) 的成年人中,持续的生长激素治疗 (GHT) 对骨矿物质密度有好处. 这支持在过渡到成人护理期间和之后持续的GHT,以改善骨健康.
科学领域:
- 内分泌学 在内分泌学.
- 儿科内分泌学 儿科内分泌学
- 骨的新陈代谢 骨的新陈代谢
背景情况:
- 儿童发病的生长激素缺乏症 (GHD) 需要生长激素治疗 (GHT) 才能达到最佳的身高.
- 终身身高后GHT停止是常见的,但潜在的长期益处,特别是对骨健康的益处,仍在研究中.
研究的目的:
- 在达到最终身高后评估持久性GHD患者的骨参数.
- 在过渡到成人护理期间,将持续接受GHT的患者的骨矿物质密度 (BMD) 和Z-分数与未接受或接受有限GHT的患者进行比较.
主要方法:
- 追溯的,单中心的观察性队列研究.
- 包括162名在1994年至2021年期间过渡到成人护理的患者.
- 在两个时间点对腰椎和部的骨矿物质密度 (BMD) 和Z分数的分析:过渡到成人护理和 >6个月后.
主要成果:
- 在第二次评估 (P = 0.034) 时,与没有GHT组相比,GHT组的腰椎脊柱BMD显著更高.
- 腰椎Z-分数显示,在GHT组 (-1.09到-0.61) 与没有GHT组 (-1.61到-1.32) (P = 0.047) 的时间中位变化明显更好.
- 两组之间没有观察到腰椎或大腿部骨质量变化的显著差异.
结论:
- 持续的GHT在患者持续的GHD在最终的高度达到后,似乎对骨矿物质密度有有益的影响.
- 这些发现支持在持续性GHD患者的成年人护理过渡期期间和之后继续GH治疗.
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