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Updated: Jan 13, 2026

Investigation of the Transcriptional Role of a RUNX1 Intronic Silencer by CRISPR/Cas9 Ribonucleoprotein in Acute Myeloid Leukemia Cells
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Investigation of the Transcriptional Role of a RUNX1 Intronic Silencer by CRISPR/Cas9 Ribonucleoprotein in Acute Myeloid Leukemia Cells

Published on: September 1, 2019

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在T细胞急性淋巴细胞白血病中,NKX2-1作为RUNX1的辅因子调节细胞生存,成熟和DNA损伤反应

Linde Van Aerschot1, Sofie Demeyer2, Kalina Timcheva1

  • 1Laboratory for Disease Mechanisms in Cancer, Department of Oncology, KU Leuven, Belgium; Laboratory for Disease Mechanisms in Cancer, Leuven Cancer Institute (LKI), Leuven.

Haematologica
|January 8, 2026
PubMed
概括

转录因子NKX2-1通过保护DNA受损而提高T细胞急性淋巴细胞白血病 (T-ALL) 细胞存活率. RUNX1充当辅助因子,表明在T-ALL病变发生过程中具有合作作用.

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