肠道微生物群和纤维肌痛中的心理痛苦:系统性审查
Biopsychosocial science and medicine
|January 8, 2026
概括
肠道微生物群的改变与纤维肌痛患者的心理痛苦有关,这表明肠道-大脑轴调节受损. 需要进一步的研究来证实肠道微生物群在纤维肌痛中的作用.
科学领域:
- 胃肠病学 胃肠病学
- 精神病学是一个精神病学.
- 微生物学 微生物学
背景情况:
- 纤维肌痛 (Fibromyalgia,简称FM) 是一种慢性疼痛疾病,通常伴有心理困扰.
- 肠道微生物群在调节生理和心理功能方面发挥着至关重要的作用.
- 新出现的证据表明肠道微生物群和FM病理生理学之间存在联系.
研究的目的:
- 系统地审查有关肠道微生物群与纤维肌痛患者心理痛苦之间的关系的最新证据.
- 综合关于微生物组变化的发现及其与FM.心理症状的关联.
- 探索纤维肌痛中肠-大脑轴的影响.
主要方法:
- 在主要数据库 (PubMed,Scopus,EBSCO,WOS,Cochrane) 进行了系统的文献搜索,遵循PRISMA指南.
- 搜索术语包括"微生物群"",心理困扰"和"纤维肌痛"的组合.
- 分析了10项英语研究,人类参与者符合纳入标准,包括病例控制,随机对照试验和观察设计.
主要成果:
- 大多数研究报告了肠道微生物失衡 (失生症),以及 FM 患者和健康对照人群之间的微生物组合或多样性的差异.
- 在FM患者中观察到肠道透性增加.
- 肠道失生症和肠道透性与更高水平的心理痛苦有关,包括情绪,认知和身体症状.
结论:
- FM患者肠道微生物群的变化支持了这种情况中肠-大脑轴调节受损的假设.
- 这些发现表明,肠道微生物群可能是纤维肌痛病理生理学的一个因素.
- 需要进一步的研究,以充分阐明微生物群-肠-大脑轴在纤维肌痛及其相关的心理痛苦中的作用.
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