超氧化物通过调节核因子红色素2相关因子1通过调节乳腺上皮细胞的自由脂肪酸诱导的炎症损伤和紧接断
Taiyu Shen1, Shijie Xia1, Yihui Huo1
1State Key Laboratory of Veterinary Public Health and Safety, College of Veterinary Medicine, China Agricultural University, Beijing 100193, China.
Journal of agricultural and food chemistry
|January 8, 2026
概括
超氧化物通过激活核因子红色素2相关因子1 (NFE2L1) 来保护乳腺上皮细胞免受损伤. 这种机制对于抵消炎症和维持性奶牛的屏障完整性至关重要.
科学领域:
- 兽医医学 兽医医学 兽医医学
- 细胞生物学 细胞生物学
- 生物化学 生物化学
背景情况:
- 乳牛的症与乳腺炎风险增加有关,但具体机制尚未完全理解.
- 核因素红色素2相关因子1 (NFE2L1) 在调节炎症反应中起作用.
- 超氧化物 (Hyp) 以其抗炎和抗氧化特性而闻名.
研究的目的:
- 为了研究超酸 (Hyp) 对乳腺上皮细胞中自由脂肪酸 (FFA) 诱导的损伤的保护机制.
- 为了确定核因子红色素2相关因子1 (NFE2L1) 在过氧化物的保护作用中的作用.
主要方法:
- 在临床性奶牛中检查了NFE2L1,紧结蛋白 (ZO-1,ocludin,claudin 1) 和炎症性细胞因子 (IL-1B,IL-6).
- 使用高度FFAs的体外模型,并用Hyp处理.
- 研究了NFE2L1沉默对Hyp的保护行动的影响.
主要成果:
- 临床性奶牛的乳腺NFE2L1和紧结蛋白减少,IL-1B和IL-6增加.
- FFAs降低了NFE2L1和紧结蛋白的表达,并激活了炎症信号.
- 过氧化物治疗逆转了这些由FFA引起的变化,这种影响取决于NFE2L1.1.
结论:
- 超氧化物通过上调NFE2L1.1,有效地保护乳腺上皮细胞免受FFA诱导的损伤.
- 这些发现表明,NFE2L1对于过氧化物在性奶牛中的抗炎和屏障保护作用至关重要.
- 超氧化物显示出作为治疗乳腺炎症的治疗剂的潜力,在性奶牛中,取决于NFE2L1活性.
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