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Updated: Jan 13, 2026

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含有循环α,α-异位氨基酸的螺旋模板:环尺寸对形状和siRNA传递的影响

Takahito Ito1, Takuma Kato2, Nobumichi Ohoka1

  • 1National Institute of Health Sciences, 3-25-26 Tonomachi, Kawasaki-ku, Kawasaki-shi, Kanagawa 210-9501, Japan.

The Journal of organic chemistry
|January 8, 2026
PubMed
概括

循环α,α-非替代氨基酸 (dAAs) 稳定了螺旋,环的大小显著影响了螺旋结构和功能. 与较大的环相比,像Ac3c这样的较小环可以引入应变,减少螺旋体的稳定性和生物活性.

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