对头支状细胞癌的新辅助免疫疗法方案的评估:系统性审查和单臂和网络元分析
Ziwu Ye1,2, Wenjie Fan1,2, Bin Zeng1,2
1Hospital of Stomatology, Guanghua School of Stomatology, Sun Yat-sen University, Guangzhou, Guangdong, People's Republic of China.
International journal of surgery (London, England)
|January 8, 2026
概括
新辅助免疫化学疗法 (NIC) 是头角状细胞癌的首选,显示出更好的病理完整反应和瘤下降阶段. 需要进一步的试验来确认最佳的治疗策略.
科学领域:
- 在瘤学瘤学.
- 免疫治疗是一种免疫疗法.
- 头部和部癌症 头部和部癌症
背景情况:
- 对头部和部状细胞癌 (HNSCC) 的最佳新辅助免疫疗法 (NAI) 选择仍在争论中.
- 本研究比较评估了可切除HNSCC的各种NAI治疗方案的临床结果.
研究的目的:
- 为了比较评估各种新辅助免疫疗法在切除的头部和部状细胞癌的临床结果.
- 确定HNSCC最佳的新辅助免疫疗法策略.
主要方法:
- 从2000年到2025年6月进行系统的文献搜索.
- 网络元分析 (NMA) 和累积排名曲线下的表面 (SUCRA) 来比较疗效 (ORR,pCR,MPR,降级) 和安全性 (irAEs).
- 44项研究 (1688名患者) 的综合分析.
主要成果:
- 新辅助免疫化学疗法 (NIC) 显示出更高的反应率:ORR 80%,pCR 40%,MPR 64%,降级 79%.
- 与NMA中的其他NAI方案相比,NIC在pCR和降级方面表现出显著的改善.
- NIC趋向于更好的生存结果,具有有利的2年OS (91%) 和DFS (90%).
结论:
- 在HNSCC中,NIC是优越的新辅助免疫疗法方案,用于实现pCR和瘤下降阶段.
- 在HNSCC治疗中,NIC应优先考虑临床决策.
- 需要进一步进行高质量的试验,以比较NAI疗法和新辅助化疗.
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