目前和新兴的方法和技术,用于快速检测尼塞利亚淋病菌的抗菌耐药性
Johan H Melendez1, Yukari C Manabe1
1Division of Infectious Diseases, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland USA.
概括
尼塞利亚淋病菌的抗菌素耐药性是一个日益严重的问题. 护理点测试可以通过快速检测抗菌素敏感性来帮助指导淋病治疗.
科学领域:
- 微生物学 微生物学
- 传染性疾病 传染性疾病
- 临床诊断 临床诊断 临床诊断
背景情况:
- 尼塞利亚淋病 (NG) 中抗微生物耐药性 (AMR) 的增加威胁着淋病治疗的有效性.
- 目前针对NG的抗微生物敏感性测试 (AST) 并非常规进行.
- 抗抗菌耐药性的点照顾 (POC) 检测可以指导治疗决策.
研究的目的:
- 审查目前和新兴的测试,以快速检测NG中的AMR.
- 讨论用于POC耐药性测试的基于核酸的新型表型方法.
- 探索实施POC淋病耐药性测试的挑战.
主要方法:
- 对NG的商业上可用的AMR测试和发展性AMR测试的文献审查.
- 对基于核酸的新型表型方法进行分析,以快速描述AMR.
- 讨论POC耐药性测试的实施因素.
主要成果:
- 针对NG的快速AMR测试的景观包括商业上可用的和开发的选择.
- 基于新型核酸的表型方法显示出POC抗性导向治疗的前景.
- 为了成功实施POC测试,需要解决几个问题.
结论:
- 对NG进行快速POCAMR测试对于对抗耐药性和指导治疗至关重要.
- 新兴技术提供了在POC及时检测耐药性的潜力.
- 成功实施需要解决实际和后勤方面的挑战.
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