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Updated: May 6, 2026

High-throughput Screening and Biosensing with Fluorescent C. elegans Strains
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High-throughput Screening and Biosensing with Fluorescent C. elegans Strains

Published on: May 19, 2011

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高通量毒性查使用C. elegans:当前的平台,主要优势和未来的方向

Timothy A Crombie1, Tobias Pamminger2, Erik C Andersen3

  • 1Department of Biomedical Engineering and Science, Florida Institute of Technology, Melbourne, Florida 32901, United States.

Environmental science & technology
|January 8, 2026
PubMed
概括

像Caenorhabditis elegans这样的虫在化学毒性高通量查 (HTS) 中具有优势. 对C. elegans的基于图像的HTS数据显示与其他物种有很强的一致性,支持它们在减少脊椎动物测试中的使用.

关键词:
凯诺哈比迪斯的优雅的植物.一个健康,一个健康.高通量测试的测试方法人类健康 人类健康 人类健康风险评估 风险评估 风险评估毒性测试 毒性测试 毒性测试

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Toxicity Testing in Animals

Toxicity tests in animals are grounded on two main assumptions: first, the effects observed in laboratory animals can be extrapolated to humans, especially when adjusted for body surface area; second, high-dose exposure in animals is essential to identify potential human hazards from lower doses. This is based on the quantal dose-response concept, which faces the challenge of extrapolating results from relatively few test animals to much larger human populations. For example, a 0.01% incidence...
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