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衰老期间抗氧化防御的组织特异性变化:慢性感冒暴露的影响

Strahinja Djuric¹, Tamara Zakic¹, Aleksandra Korac²

¹Institute for Biological Research "Sinisa Stankovic", National Institute of the Republic of Serbia, University of Belgrade, Belgrade, Serbia.

Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology

|January 8, 2026

概括

长期暴露于寒冷会增强老老鼠的抗氧化防御能力,特别是在棕色脂肪组织中,这表明,尽管长期衰老,但对环境压力的反应仍然存在.

科学领域:

生理学生理学生理学
衰老研究研究衰老研究
代谢过程中的代谢.

背景情况:

衰老与氧化还原平衡失调有关.
关于慢性感冒暴露对老老鼠抗氧化防御的影响的数据有限.

研究的目的:

为了研究慢性感冒暴露对老老鼠抗氧化剂防御成分的影响.
为了在不同的组织中比较这些效应:骨间棕色脂肪组织 (iBAT),后白色脂肪组织 (rWAT),骨肌肉和肝脏.

主要方法:

评估了年轻 (3个月大),老年 (24个月大) 和暴露于寒冷的老老鼠 (4°C从6到24个月) 组织中的抗氧化剂防御成分 (酶活性和谷氨含量).
测量了超氧化物转化酶 (SOD),催化酶,谷氨酸过氧化酶 (GSH-Px),谷氨酸减少酶 (GR),硫素减少酶 (TR),谷氨酸S转移酶 (GST) 和谷氨酸 (GSH).

主要成果:

慢性衰老降低了rWAT和iBAT中的抗氧化酶.
与年龄相匹配的对照组相比,暴露于寒冷的老老鼠在rWAT,iBAT和肌肉中显示出高调的抗氧化剂防御.
在各组中,SOD活性和肝脏抗氧化成分基本保持不变.

结论:

抗氧化剂防御配置的明显调节发生在不同器官的衰老和冷暴露.
老老鼠对长时间暴露在寒冷中表现出一种保存的抗氧化剂防御反应,特别是在热源性IBAT中.

关键词:

年龄化衰老衰老抗氧化剂防御的抗氧化剂防御寒冷的寒冷的寒冷的寒冷的寒冷的寒冷肝脏肝脏肝脏肝脏骨架肌肉是一个骨肌肉.在iBATAT中,您可以使用iBAT.rWAT 的意思是什么?

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