相关实验视频

Updated: Jan 13, 2026

A Murine Cell Line Based Model of Chronic CDK9 Inhibition to Study Widespread Non-Genetic Transcriptional Elongation Defects TEdeff in Cancers
10:49

A Murine Cell Line Based Model of Chronic CDK9 Inhibition to Study Widespread Non-Genetic Transcriptional Elongation Defects TEdeff in Cancers

Published on: September 26, 2019

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破坏CDK9活性抑制三阴性乳腺癌,并通过EGFR抑制增强

Vera E van der Noord1, Ronan P McLaughlin2, Jessica S Karuntu2

  • 1Division of Cell Systems and Drug Safety, Leiden Academic Centre for Drug Research, Leiden University, Einsteinweg 55, 2333 CC, Leiden, 2300 RA, The Netherlands. v.e.van.der.noord@lacdr.leidenuniv.nl.

Cellular oncology (Dordrecht, Netherlands)
|January 8, 2026
PubMed
概括

新型CDK9抑制剂在治疗三阴性乳腺癌 (TNBC) 方面表现有前途. 单独或与EGFR抑制剂一起向CDK9,减少瘤生长和诱导癌细胞死亡,为TNBC提供新的治疗途径.

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