系统性炎症反应指数与风湿关节炎患者心血管疾病风险之间的关联:基于美国和中国队列的机器学习
Pengyu Zhang1, Sining Wang1, Taijin Wu2
1Department of Nephrology and Rheumatology, Tongde Hospital of Zhejiang Province, Hangzhou, 310012, China.
Clinical rheumatology
|January 8, 2026
概括
系统性炎症反应指数 (SIRI) 与类风湿性关节炎 (RA) 中的心血管疾病 (CVD) 风险有关. SIRI 改善了 RA 患者的心血管疾病风险预测,有助于早期识别和管理.
科学领域:
- 类风湿病学 类风湿病学
- 心脏病学 心脏病学
- 炎症研究 炎症研究
背景情况:
- 类风湿性关节炎 (RA) 患者的心血管疾病 (CVD) 发病率很高.
- 系统性炎症反应指数 (SIRI) 显示了炎症和心血管疾病的预测效用.
- 特别是在RA患者群体中,SIRI和心血管疾病风险之间的关联需要进一步调查.
研究的目的:
- 研究RA患者SIRI和心血管疾病风险之间的关系.
- 评估SIRI在确定RA中心血管疾病风险方面的预测性能.
- 评估SIRI是否可以增强RA中现有的心血管风险评估模型.
主要方法:
- 利用培训,时间验证和外部验证数据集 (NHANES,中国队列).
- 采用多变量逻辑回归和受限立方线函数来分析SIRI-CVD风险关联.
- 通过ROC分析和重新分类指标,评估SIRI的增量值,当它被添加到Framingham风险评分时.
主要成果:
- 在RA患者中,SIRI和心血管疾病风险之间发现了显著的积极关联 (P = 0.003).
- 与最低三位数 (OR = 2.028) 相比,SIRI三位数最高的人患心血管疾病的风险增加了两倍.
- 将SIRI集成到Framingham风险评分中,提高了所有验证数据集的预测准确性.
结论:
- 在RA中,SIRI是心血管疾病风险的显著积极预测指标.
- SIRI增强了Framingham风险评分对RA患者的预测能力.
- 在RA中,SIRI可以作为一种有价值的生物标志物,用于早期发现和管理心血管疾病风险.
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