对于正在接受激素治疗的前列腺癌患者,-葡萄糖共载体2抑制剂
Ruofan Shi1,2, Yongle Zhan1,3, Ruochen Ma1
1Division of Urology, Department of Surgery, School of Clinical Medicine, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, China.
JAMA oncology
|January 8, 2026
概括
-葡萄糖共运输体2 (SGLT2) 抑制剂可能在前列腺癌中提供抗瘤益处. 它们在激素治疗期间的使用与延迟的雄激素剥夺治疗失败有关,这表明潜在的瘤优势.
科学领域:
- 在瘤学瘤学.
- 内分泌学 在内分泌学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 初步证据表明,-葡萄糖共运输体2 (SGLT2) 抑制剂可能具有抗瘤原源性质.
- 在前列腺癌治疗中SGLT2抑制剂的潜在益处在很大程度上仍未被探索.
- 了解它们在激素治疗期间对结果的影响对于开发辅助治疗策略至关重要.
研究的目的:
- 调查SGLT2抑制剂使用与接受激素治疗的前列腺癌患者的临床结果之间的关联.
- 评估SGLT2抑制剂在延缓治疗失败和改善该患者群体的存活率方面的疗效.
主要方法:
- 一个以人口为基础的,使用香港电子健康记录 (1993-2025) 的顺序目标试验模拟.
- 包括患有前列腺癌的成年男性启动雄激素剥夺疗法 (ADT).
- 对使用SGLT2抑制剂 (达帕格利弗洛辛,恩帕格利弗洛辛) 与不使用SGLT2抑制剂的分析,评估ADT失效的时间,下一代荷尔蒙药物失效,疾病特异性存活率和整体存活率.
主要成果:
- 在14223名患者中,使用SGLT2抑制剂与ADT失败 (HR,0.63) 和下一代荷尔蒙药物失败 (HR,0.44) 的风险降低有关.
- 甲胺单疗没有显示与疾病进展的相关性,但改善了整体存活率 (HR,0.59).
- 在达帕格利弗洛辛和empagliflozin之间没有观察到任何显著的差异.
结论:
- 使用SGLT2抑制剂与前列腺癌患者的延迟激素治疗失败有关.
- 这些发现表明,SGLT2抑制剂的潜在瘤益处超出了降糖效应.
- 作为前列腺癌的潜在辅助治疗,SGLT2抑制剂显示出有前途.
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