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相关概念视频

Olfaction01:25

Olfaction

48.1K
The sense of smell is achieved through the activities of the olfactory system. It starts when an airborne odorant enters the nasal cavity and reaches olfactory epithelium (OE). The OE is protected by a thin layer of mucus, which also serves the purpose of dissolving more complex compounds into simpler chemical odorants. The size of the OE and the density of sensory neurons varies among species; in humans, the OE is only about 9-10 cm2.
The olfactory receptors are embedded in the cilia of the...
48.1K
Olfactory Receptors: Location and Structure01:03

Olfactory Receptors: Location and Structure

11.1K
The process of olfaction, also known as the sense of smell, is a sophisticated chemical response system. The specialized sensory neurons that facilitate this process, known as olfactory receptor neurons, are situated in an upper segment of the nasal cavity, known as the olfactory epithelium. Olfactory sensory neurons are bipolar, with their dendrites extending from the epithelium's apex into the mucus that lines the nasal cavity. Airborne molecules, when inhaled, traverse the olfactory...
11.1K
Physiology of Smell and Olfactory Pathway01:20

Physiology of Smell and Olfactory Pathway

12.2K
Humans detect odors with the help of specialized cells located in the upper part of the nasal cavity, called olfactory receptor neurons (ORNs). ORNs possess hair-like structures called cilia, which are receptive to sensations from the inhaled air. When an odorant molecule binds to a specific receptor on the cell of the cilia, it leads to a series of events that ultimately cause the ORN to send electrical signals to the olfactory bulb in the brain through the olfactory nerves.
The olfactory...
12.2K

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相关实验视频

Updated: Jan 13, 2026

Olfactory Assays for Mouse Models of Neurodegenerative Disease
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一个基于应用的新型测试,用于快速选嗅觉功能障碍.

Benjamin J Bernard1, Omer Baker2, Alena Pauley2

  • 1Department of Otolaryngology-Head and Neck Surgery, University of California, San Diego, La Jolla.

JAMA otolaryngology-- head & neck surgery
|January 8, 2026
PubMed
概括

一个新的移动应用程序有效地选嗅觉功能障碍 (OD),这是一个常见的情况. 这种工具快速,可靠,与现有的临床用气味测试相关.

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Simple and Computer-assisted Olfactory Testing for Mice
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相关实验视频

Last Updated: Jan 13, 2026

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07:27

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科学领域:

  • 神经学 神经学
  • 耳鼻喉科 耳鼻喉科 耳鼻喉科
  • 医学诊断 医学诊断 医学诊断

背景情况:

  • 嗅觉功能障碍 (OD) 是普遍存在的,并且经常被低诊断,造成发病率和死亡率的风险.
  • 目前的气味测试通常是昂贵的,耗时的,并且难以扩展.

研究的目的:

  • 评估一种基于移动应用程序的新型,自我管理的嗅觉查工具的诊断性能.

主要方法:

  • 一项诊断研究涉及484名英语成年人 (≥18岁) 在美国学术医疗中心.
  • 参与者完成了5项移动应用气味识别测试;一个子组也进行了比较测试.

主要成果:

  • 这种新型测试显示出良好的诊断准确性,曲线下的面积为0.87 (95% CI,0.78-0.96).
  • 敏感度为74% (95% CI,51%-88%) 和特异性为86% (95% CI,72%-93%) 在切断值<3.3时.
  • 测试得分与对比测试 (r=0.74) 和主观嗅觉 (r=0.34) 相对相关,显示可接受的内部一致性.

结论:

  • 基于移动应用程序的嗅觉查工具是一种快速,可靠的方法来检测OD.
  • 该工具显示出广泛临床使用和纵向监测嗅觉功能的潜力.