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Updated: Jan 13, 2026

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通过SIRT2去乙MRE11,促进DNA结合,以促进DNA末端切除和ATM依赖的信号传递

Fatmata Sesay1, Hui Zhang1, Priya Kapoor-Vazirani1

  • 1Department of Radiation Oncology and Winship Cancer Institute, Emory University School of Medicine, Atlanta, United States of America.

The Journal of clinical investigation
|January 8, 2026
PubMed
概括

氨酸脱甲基酶SIRT2在lysine 393处脱甲基化MRE11,促进其DNA结合并促进DNA修复. 这种SIRT2-MRE11相互作用对于DNA损伤反应和预防基因组不稳定性至关重要.

关键词:
细胞生物学 细胞生物学修复DNA的修复DNA的修复在瘤学瘤学.放射治疗疗法 放射治疗疗法

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