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孟加拉国NPSLE患者对维生素D3补充剂对认知功能的初步经验

Nasreen Sultana¹, Md Amimul Ihsan², Sheikh Md Adnan¹

¹National Institute of Nuclear Medicine and Allied Sciences, Bangladesh Atomic Energy Commission (BAEC), Dhaka, Bangladesh.

Nutrition and health

|January 8, 2026

概括

这项研究表明,维生素D3补充剂改善了神经精神病系统性红斑狼 (NPSLE) 患者的认知功能. 维生素D3还增强了大脑输液,表明它有可能作为NPSLE的辅助疗法.

科学领域:

神经科学是一个神经科学.
免疫学免疫学免疫学
内分泌学在内分泌学.

背景情况:

系统性红斑狼 (SLE) 是一种影响多个器官的自身免疫性疾病,经常导致神经精神病症状 (NPSLE).
认知功能障碍是NPSLE的一个普遍表现,显著降低了患者的生活质量.
维生素D3,以神经保护和认知益处而闻名,为NPSLE提供了潜在的治疗途径.

研究的目的:

研究维生素D3补充剂在改善NPSLE患者认知功能的有效性.
评估维生素D3对血清维生素D水平和NPSLE脑 perfusion的影响.

主要方法:

一项随机对照试验,涉及72名接受标准SLE护理的NPSLE患者.
干预组 (n=34) 接受每周维生素D3 (40,000 IU) 6周,随后每天 (2000 IU) 3个月;对照组 (n=38) 不接受补充.
认知功能 (MMSE),血清维生素D3水平和脑 perfusion (SPECT) 在基线和6个月后被测量.

主要成果:

在干预组中,维生素D3补充剂显著增加了血清维生素D3度 (16.2至28.3 ng/mL,P≤0.001).
与对照组相比,干预组在迷你心理状态检查 (MMSE) 得分上显示出显著更大的改善 (平均差异为2.2与0.3).
分析显示,维生素D度的效果大 (η2p=0.714) 和MMSE得分的效果大小中等 (η2p=0.460),趋势是改善大脑输液.

结论:

维生素D3补充剂在增加NPSLE患者血清维生素D水平方面是有效的.
补充维生素D3导致NPSLE患者认知功能和大脑 perfusion 显著改善.
维生素D3作为一种辅助疗法,有望在NPSLE中管理认知功能障碍和神经症状.

关键词:

这是一个MMSE.在 NPSLE 中.斯佩克特 (Spectre) 是一个运动场.认知功能障碍认知功能障碍维生素D是维生素D的重要组成部分.

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