白细胞计数与艾滋病毒感染者死亡的关联:一项长度研究超过24年
Zoe Klein1, Sophia C Meyer1, Isabella C Schoepf1,2
1University Center for Internal Medicine and Infectious Diseases Service, Kantonsspital Baselland, Department of Clinical Research, University Hospital Basel, University of Basel, Bruderholz, Switzerland.
PloS one
|January 8, 2026
概括
血白细胞数量高或低与艾滋病毒感染者的死亡率增加有关. 这种关联甚至在白细胞水平处于典型范围内并且在死亡前一年内测量时也存在.
科学领域:
- 免疫学 免疫学 免疫学
- 流行病学 流行病学
- 临床医学 临床医学
背景情况:
- 血白细胞升高是一个已知的死亡风险因素在一般人群.
- 有限的数据存在于白细胞计数和死亡率之间的关联,特别是在患有人类免疫缺陷病毒 (HIV) 的人群中.
研究的目的:
- 为了研究血白细胞计数与艾滋病毒感染者全因死亡率之间的关联.
- 要确定这种关联是否根据白细胞测量相对于死亡的时间不同.
主要方法:
- 分析了从1850名已故的瑞士艾滋病毒队列研究参与者和1850名匹配对照的血白细胞计数.
- 在死亡前一年以上测量的白细胞水平的评估以及最新可用的血液样本.
- 多变量逻辑回归以调整临床和艾滋病毒相关死亡风险因素.
主要成果:
- 在白细胞计数和死亡率之间观察到U形的关联.
- 高 (≥7730/μL) 和低 (≤4250/μL) 白细胞计数都与死亡前1年测量时的全因死亡率 (OR=1.56和1.51) 的增加独立相关.
- 在最新的血液样本中,高白细胞计数 (OR=1.99) 的相关性更强. 高白细胞与非艾滋病/非肝癌,心血管和呼吸道死亡相关,而低白细胞与与肝脏有关的死亡率有关.
结论:
- 高白细胞计数,即使在正常范围内,并在一年前测量,独立地与艾滋病毒感染者的死亡率增加有关.
- 白血球数作为这一群体死亡率的显著预后标志物.
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